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Elkington PT, Cooke GS MMP12, lung function, and COPD in high-risk populations. N Engl J Med 362: 1241. 16. Haq I, Chappell S, Johnson SR, Lotya J, Daly L, et al. Association of MMP-2 polymorphisms with serious and quite serious COPD: a case manage study of MMPs-1, 9 and 12 inside a European population. BMC Med Genet 11: 7. 17. Zheng T, Zhu Z, Wang Z, Homer RJ, Ma B, et al. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsindependent emphysema. J Clin Invest 106: 108193. 18. van der Pouw Kraan TC, van Veen A, Boeije LC, van Tuyl SA, de Groot ER, et al. An IL-13 promoter polymorphism associated with elevated threat of allergic asthma. Genes Immun 1: 6165. 19. van der Pouw Kraan TCTM, Kucukaycan M, Bakker AM, Baggen JMC, van der Zeehttp://www.nature.com/gene/journal/v3/n7/abs/6363896a.html aff4 JS, et al. Chronic obstructive pulmonary disease is associated with the -1055 IL-13 promoter polymorphism. Genes and Immunity 3: 436439. 20. Sadeghnejad A, Meyers DA, Bottai M, Sterling DA, Bleecker ER, et al. IL13 promoter polymorphism 1112C/T modulates the adverse impact of tobacco smoking on lung function. Am J Respir Crit Care Med 176: 74852. 21. Morris DG, Huang X, Kaminski N, Wang Y, Shapiro SD, et al. Loss of integrin alphabeta6-mediated TGFbeta activation causes Mmp12-dependent emphysema. Nature 422: 16973. five COPD in South Indian Male Smokers 22. Roberts AB Medicine: Smoke signals for lung disease. Nature 422: 1301. 23. Grainger DJ, Heathcote K, Chiano M, Snieder H, Kemp PR, et al. Genetic handle from the circulating concentration of transforming growth issue sort beta1. Hum. Mol. Genet 8: 9397. 24. Celedon JC, Lange C, Raby BA, Litonjua AA, Palmer LJ, et al. The transforming development factor-beta1 gene is related to chronic obstructive pulmonary disease. Hum Mol Genet 13: 164956. 25. Cantlay AM, Smith CA, Wallace WA, Yap PL, Lamb D, et al. Heterogeneous expression and polymorphic genotype of glutathione Stransferases in human lung. Thorax 49: 10104. 26. Zimniak P, Nanduri B, Pikula S, Bandorowicz-Pikula J, Singhal SS, et al. Naturally occurring human glutathione S-transferase GSTP11 isoforms with isoleucine and valine in position 104 differ in enzymic properties. Eur. J. Biochem 17493865 224: 893899. 27. Sundberg K, Johansson A, Stenberg G, Widersten M, Seidel A, et al. Variations inside the catalytic efficiences of allelic variants of glutathione transferase P11 towardscarcinogenic diol epoxides of polycyclic aromatic hydrocarbons.Carcinogenesis, 19: 433436. 28. Ryberg D, Skaug V, Hewer A, Phillips DH, Harries LW, et al. Genotypes of.Hao Handbook on analyzing human genetic data: computational approaches and application. Heidelberg; New York: Springer. 11. Benjamini Y, Hochberg Y Controlling the false discovery rate: a sensible and effective strategy to a number of testing. J R Statist Soc B 57: 289300. 12. Caramori G, Di Gregorio C, Carlstedt I, Casolari P, Guzzinati I, et al. Mucin expression in peripheral airways of sufferers with chronic obstructive pulmonary illness. Histopathology 45: 477484. 13. Hautamaki RD, Kobayashi DK, Senior RM, Shapiro SD Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 277: 20022004. 14. Jormsjo S, Ye S, Moritz J, Walter DH, Dimmeler,S, etal. Allele-specific regulation of matrix metalloproteinase-12 gene activity is linked to coronary artery luminal dimensions in diabetic sufferers with manifest coronary artery illness. Circ Res 86: 9981003. 15. Elkington PT, Cooke GS MMP12, lung function, and COPD in high-risk populations. N Engl J Med 362: 1241. 16. Haq I, Chappell S, Johnson SR, Lotya J, Daly L, et al. Association of MMP-2 polymorphisms with severe and really extreme COPD: a case handle study of MMPs-1, 9 and 12 within a European population. BMC Med Genet 11: 7. 17. Zheng T, Zhu Z, Wang Z, Homer RJ, Ma B, et al. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsindependent emphysema. J Clin Invest 106: 108193. 18. van der Pouw Kraan TC, van Veen A, Boeije LC, van Tuyl SA, de Groot ER, et al. An IL-13 promoter polymorphism connected with elevated threat of allergic asthma. Genes Immun 1: 6165. 19. van der Pouw Kraan TCTM, Kucukaycan M, Bakker AM, Baggen JMC, van der Zeehttp://www.nature.com/gene/journal/v3/n7/abs/6363896a.html aff4 JS, et al. Chronic obstructive pulmonary disease is connected with the -1055 IL-13 promoter polymorphism. Genes and Immunity three: 436439. 20. Sadeghnejad A, Meyers DA, Bottai M, Sterling DA, Bleecker ER, et al. IL13 promoter polymorphism 1112C/T modulates the adverse effect of tobacco smoking on lung function. Am J Respir Crit Care Med 176: 74852. 21. Morris DG, Huang X, Kaminski N, Wang Y, Shapiro SD, et al. Loss of integrin alphabeta6-mediated TGFbeta activation causes Mmp12-dependent emphysema. Nature 422: 16973. 5 COPD in South Indian Male Smokers 22. Roberts AB Medicine: Smoke signals for lung disease. Nature 422: 1301. 23. Grainger DJ, Heathcote K, Chiano M, Snieder H, Kemp PR, et al. Genetic handle on the circulating concentration of transforming development element variety beta1. Hum. Mol. Genet 8: 9397. 24. Celedon JC, Lange C, Raby BA, Litonjua AA, Palmer LJ, et al. The transforming development factor-beta1 gene is connected with chronic obstructive pulmonary illness. Hum Mol Genet 13: 164956. 25. Cantlay AM, Smith CA, Wallace WA, Yap PL, Lamb D, et al. Heterogeneous expression and polymorphic genotype of glutathione Stransferases in human lung. Thorax 49: 10104. 26. Zimniak P, Nanduri B, Pikula S, Bandorowicz-Pikula J, Singhal SS, et al. Naturally occurring human glutathione S-transferase GSTP11 isoforms with isoleucine and valine in position 104 differ in enzymic properties. Eur. J. Biochem 17493865 224: 893899. 27. Sundberg K, Johansson A, Stenberg G, Widersten M, Seidel A, et al. Variations within the catalytic efficiences of allelic variants of glutathione transferase P11 towardscarcinogenic diol epoxides of polycyclic aromatic hydrocarbons.Carcinogenesis, 19: 433436. 28. Ryberg D, Skaug V, Hewer A, Phillips DH, Harries LW, et al. Genotypes of.
