Hao Handbook on analyzing human genetic data: computational approaches and computer software. Heidelberg; New York: inhibitor Springer. 11. Benjamini Y, Hochberg Y Controlling the false discovery rate: a practical and strong approach to many testing. J R Statist Soc B 57: 289300. 12. Caramori G, Di Gregorio C, Carlstedt I, Casolari P, Guzzinati I, et al. Mucin expression in peripheral airways of sufferers with chronic obstructive pulmonary disease. Histopathology 45: 477484. 13. Hautamaki RD, Kobayashi DK, Senior RM, Shapiro SD Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 277: 20022004. 14. Jormsjo S, Ye S, Moritz J, Walter DH, Dimmeler,S, etal. Allele-specific regulation of matrix metalloproteinase-12 gene activity is linked to coronary artery luminal dimensions in diabetic patients with manifest coronary artery illness. Circ Res 86: 9981003. 15. Elkington PT, Cooke GS MMP12, lung function, and COPD in high-risk populations. N Engl J Med 362: 1241. 16. Haq I, Chappell S, Johnson SR, Lotya J, Daly L, et al. Association of MMP-2 polymorphisms with severe and extremely serious COPD: a case control study of MMPs-1, 9 and 12 inside a European population. BMC Med Genet 11: 7. 17. Zheng T, Zhu Z, Wang Z, Homer RJ, Ma B, et al. Inducible targeting of IL-13 towards the adult lung causes matrix metalloproteinase- and cathepsindependent emphysema. J Clin Invest 106: 108193. 18. van der Pouw Kraan TC, van Veen A, Boeije LC, van Tuyl SA, de Groot ER, et al. An IL-13 promoter polymorphism related to improved threat of allergic asthma. Genes Immun 1: 6165. 19. van der Pouw Kraan TCTM, Kucukaycan M, Bakker AM, Baggen JMC, van der Zeehttp://www.nature.com/gene/journal/v3/n7/abs/6363896a.html aff4 JS, et al. Chronic obstructive pulmonary disease is connected with the -1055 IL-13 promoter polymorphism. Genes and Immunity 3: 436439. 20. Sadeghnejad A, Meyers DA, Bottai M, Sterling DA, Bleecker ER, et al. IL13 promoter polymorphism 1112C/T modulates the inhibitor adverse impact of tobacco smoking on lung function. Am J Respir Crit Care Med 176: 74852. 21. Morris DG, Huang X, Kaminski N, Wang Y, Shapiro SD, et al. Loss of integrin alphabeta6-mediated TGFbeta activation causes Mmp12-dependent emphysema. Nature 422: 16973. five COPD in South Indian Male Smokers 22. Roberts AB Medicine: Smoke signals for lung illness. Nature 422: 1301. 23. Grainger DJ, Heathcote K, Chiano M, Snieder H, Kemp PR, et al. Genetic manage in the circulating concentration of transforming growth aspect sort beta1. Hum. Mol. Genet eight: 9397. 24. Celedon JC, Lange C, Raby BA, Litonjua AA, Palmer LJ, et al. The transforming development factor-beta1 gene is associated with chronic obstructive pulmonary disease. Hum Mol Genet 13: 164956. 25. Cantlay AM, Smith CA, Wallace WA, Yap PL, Lamb D, et al. Heterogeneous expression and polymorphic genotype of glutathione Stransferases in human lung. Thorax 49: 10104. 26. Zimniak P, Nanduri B, Pikula S, Bandorowicz-Pikula J, Singhal SS, et al. Naturally occurring human glutathione S-transferase GSTP11 isoforms with isoleucine and valine in position 104 differ in enzymic properties. Eur. J. Biochem 17493865 224: 893899. 27. Sundberg K, Johansson A, Stenberg G, Widersten M, Seidel A, et al. Differences in the catalytic efficiences of allelic variants of glutathione transferase P11 towardscarcinogenic diol epoxides of polycyclic aromatic hydrocarbons.Carcinogenesis, 19: 433436. 28. Ryberg D, Skaug V, Hewer A, Phillips DH, Harries LW, et al. Genotypes of.Hao Handbook on analyzing human genetic information: computational approaches and application. Heidelberg; New York: Springer. 11. Benjamini Y, Hochberg Y Controlling the false discovery price: a sensible and powerful approach to a number of testing. J R Statist Soc B 57: 289300. 12. Caramori G, Di Gregorio C, Carlstedt I, Casolari P, Guzzinati I, et al. Mucin expression in peripheral airways of patients with chronic obstructive pulmonary disease. Histopathology 45: 477484. 13. Hautamaki RD, Kobayashi DK, Senior RM, Shapiro SD Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 277: 20022004. 14. Jormsjo S, Ye S, Moritz J, Walter DH, Dimmeler,S, etal. Allele-specific regulation of matrix metalloproteinase-12 gene activity is connected with coronary artery luminal dimensions in diabetic individuals with manifest coronary artery disease. Circ Res 86: 9981003. 15. Elkington PT, Cooke GS MMP12, lung function, and COPD in high-risk populations. N Engl J Med 362: 1241. 16. Haq I, Chappell S, Johnson SR, Lotya J, Daly L, et al. Association of MMP-2 polymorphisms with serious and pretty extreme COPD: a case manage study of MMPs-1, 9 and 12 inside a European population. BMC Med Genet 11: 7. 17. Zheng T, Zhu Z, Wang Z, Homer RJ, Ma B, et al. Inducible targeting of IL-13 for the adult lung causes matrix metalloproteinase- and cathepsindependent emphysema. J Clin Invest 106: 108193. 18. van der Pouw Kraan TC, van Veen A, Boeije LC, van Tuyl SA, de Groot ER, et al. An IL-13 promoter polymorphism related to improved risk of allergic asthma. Genes Immun 1: 6165. 19. van der Pouw Kraan TCTM, Kucukaycan M, Bakker AM, Baggen JMC, van der Zeehttp://www.nature.com/gene/journal/v3/n7/abs/6363896a.html aff4 JS, et al. Chronic obstructive pulmonary illness is associated with the -1055 IL-13 promoter polymorphism. Genes and Immunity three: 436439. 20. Sadeghnejad A, Meyers DA, Bottai M, Sterling DA, Bleecker ER, et al. IL13 promoter polymorphism 1112C/T modulates the adverse effect of tobacco smoking on lung function. Am J Respir Crit Care Med 176: 74852. 21. Morris DG, Huang X, Kaminski N, Wang Y, Shapiro SD, et al. Loss of integrin alphabeta6-mediated TGFbeta activation causes Mmp12-dependent emphysema. Nature 422: 16973. 5 COPD in South Indian Male Smokers 22. Roberts AB Medicine: Smoke signals for lung disease. Nature 422: 1301. 23. Grainger DJ, Heathcote K, Chiano M, Snieder H, Kemp PR, et al. Genetic manage from the circulating concentration of transforming development aspect sort beta1. Hum. Mol. Genet eight: 9397. 24. Celedon JC, Lange C, Raby BA, Litonjua AA, Palmer LJ, et al. The transforming development factor-beta1 gene is linked to chronic obstructive pulmonary disease. Hum Mol Genet 13: 164956. 25. Cantlay AM, Smith CA, Wallace WA, Yap PL, Lamb D, et al. Heterogeneous expression and polymorphic genotype of glutathione Stransferases in human lung. Thorax 49: 10104. 26. Zimniak P, Nanduri B, Pikula S, Bandorowicz-Pikula J, Singhal SS, et al. Naturally occurring human glutathione S-transferase GSTP11 isoforms with isoleucine and valine in position 104 differ in enzymic properties. Eur. J. Biochem 17493865 224: 893899. 27. Sundberg K, Johansson A, Stenberg G, Widersten M, Seidel A, et al. Differences within the catalytic efficiences of allelic variants of glutathione transferase P11 towardscarcinogenic diol epoxides of polycyclic aromatic hydrocarbons.Carcinogenesis, 19: 433436. 28. Ryberg D, Skaug V, Hewer A, Phillips DH, Harries LW, et al. Genotypes of.
