: 267274. 10. Tuder RM, Davis LA, Graham BB Targeting energetic metabolism: a brand new frontier within the pathogenesis and treatment of pulmonary hypertension. Am J Respir Crit Care Med 185: 260266. 11. Pugh ME, Robbins IM, Rice TW, West J, Newman JH, et 1480666 al. Unrecognized glucose intolerance is typical in pulmonary arterial hypertension. J Heart Lung Transplant 30: 904911. 12. Hansmann G, Wagner RA, Schellong S, Perez VA, Urashima T, et al. Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation. Circulation 115: 12751284. 13. Archer SL, Weir EK, Wilkins MR Fundamental science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies. Circulation 121: 20452066. 14. Sutendra G, Bonnet S, Rochefort G, Haromy A, Folmes KD, et al. Fatty acid oxidation and malonyl-CoA decarboxylase within the vascular remodeling of pulmonary hypertension. Sci Transl Med two: 44ra58. 15. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, et al. Metabolomic profiles Licochalcone-A web delineate potential role for sarcosine in prostate cancer progression. Nature 457: 910914. 10 Metabolomic Heterogeneity of PAH 16. Lazarow PB Rat liver peroxisomes catalyze the beta oxidation of fatty acids. J Biol Chem 253: 15221528. 17. Kunau WH, Dommes V, Schulz H beta-oxidation of fatty acids in mitochondria, peroxisomes, and bacteria: a century of continued progress. Prog Lipid Res 34: 267342. 18. Zhao YD, Courtman DW, Deng Y, Kugathasan L, Zhang Q, et al. Rescue of monocrotaline-induced pulmonary arterial hypertension employing bone marrow-derived endothelial-like progenitor cells: efficacy of combined cell and eNOS gene therapy in established illness. Circ Res 96: 442450. 19. Piao L, Fang YH, Cadete VJ, Wietholt C, Urboniene D, et al. The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of ideal ventricular hypertrophy: resuscitating the hibernating proper ventricle. J Mol Med 88: 4760. 20. Shimoda LA, Manalo DJ, Sham JS, Semenza GL, Sylvester JT Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia. Am J Physiol Lung Cell Mol Physiol 281: L202208. 21. Michelakis ED, McMurtry MS, Wu XC, Dyck JR, Moudgil R, et al. Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic 22. 23. 24. 25. 26. 27. pulmonary hypertension in rats: function of increased expression and activity of voltage-gated potassium channels. Circulation 105: 244250. McMurtry MS, Bonnet S, Wu X, Dyck JR, Haromy A, et al. Dichloroacetate prevents and reverses pulmonary hypertension by 61177-45-5 inducing pulmonary artery smooth muscle cell apoptosis. Circ Res 95: 830840. Warburg O On the origin of cancer cells. Science 123: 309314. Trachootham D, Lu W, Ogasawara MA, Nilsa RD, Huang P Redox regulation of cell survival. Antioxid Redox Signal ten: 13431374. Nordlie RC, Foster JD A retrospective overview on the roles of multifunctional glucose-6-phosphatase in blood glucose homeostasis: Genesis from the tuning/retuning hypothesis. Life Sci 87: 339349. Neermann J, Wagner R Comparative analysis of glucose and glutamine metabolism in transformed mammalian cell lines, insect and primary liver cells. J Cell Physiol 166: 152169. Zhou KG, Jiang LJ, Shang Z, Wang J, Huang L, et al. Potential application of IDH1 and IDH2 mutations as prognostic indicators in nonpromyelocytic acute myeloid leukemia: a meta-analysis. Leuk Lymphom.: 267274. 10. Tuder RM, Davis LA, Graham BB Targeting energetic metabolism: a new frontier inside the pathogenesis and therapy of pulmonary hypertension. Am J Respir Crit Care Med 185: 260266. 11. Pugh ME, Robbins IM, Rice TW, West J, Newman JH, et 1480666 al. Unrecognized glucose intolerance is widespread in pulmonary arterial hypertension. J Heart Lung Transplant 30: 904911. 12. Hansmann G, Wagner RA, Schellong S, Perez VA, Urashima T, et al. Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation. Circulation 115: 12751284. 13. Archer SL, Weir EK, Wilkins MR Simple science of pulmonary arterial hypertension for clinicians: new ideas and experimental therapies. Circulation 121: 20452066. 14. Sutendra G, Bonnet S, Rochefort G, Haromy A, Folmes KD, et al. Fatty acid oxidation and malonyl-CoA decarboxylase inside the vascular remodeling of pulmonary hypertension. Sci Transl Med 2: 44ra58. 15. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, et al. Metabolomic profiles delineate potential function for sarcosine in prostate cancer progression. Nature 457: 910914. ten Metabolomic Heterogeneity of PAH 16. Lazarow PB Rat liver peroxisomes catalyze the beta oxidation of fatty acids. J Biol Chem 253: 15221528. 17. Kunau WH, Dommes V, Schulz H beta-oxidation of fatty acids in mitochondria, peroxisomes, and bacteria: a century of continued progress. Prog Lipid Res 34: 267342. 18. Zhao YD, Courtman DW, Deng Y, Kugathasan L, Zhang Q, et al. Rescue of monocrotaline-induced pulmonary arterial hypertension applying bone marrow-derived endothelial-like progenitor cells: efficacy of combined cell and eNOS gene therapy in established disease. Circ Res 96: 442450. 19. Piao L, Fang YH, Cadete VJ, Wietholt C, Urboniene D, et al. The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of ideal ventricular hypertrophy: resuscitating the hibernating appropriate ventricle. J Mol Med 88: 4760. 20. Shimoda LA, Manalo DJ, Sham JS, Semenza GL, Sylvester JT Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia. Am J Physiol Lung Cell Mol Physiol 281: L202208. 21. Michelakis ED, McMurtry MS, Wu XC, Dyck JR, Moudgil R, et al. Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic 22. 23. 24. 25. 26. 27. pulmonary hypertension in rats: part of elevated expression and activity of voltage-gated potassium channels. Circulation 105: 244250. McMurtry MS, Bonnet S, Wu X, Dyck JR, Haromy A, et al. Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis. Circ Res 95: 830840. Warburg O Around the origin of cancer cells. Science 123: 309314. Trachootham D, Lu W, Ogasawara MA, Nilsa RD, Huang P Redox regulation of cell survival. Antioxid Redox Signal ten: 13431374. Nordlie RC, Foster JD A retrospective review of your roles of multifunctional glucose-6-phosphatase in blood glucose homeostasis: Genesis in the tuning/retuning hypothesis. Life Sci 87: 339349. Neermann J, Wagner R Comparative analysis of glucose and glutamine metabolism in transformed mammalian cell lines, insect and major liver cells. J Cell Physiol 166: 152169. Zhou KG, Jiang LJ, Shang Z, Wang J, Huang L, et al. Possible application of IDH1 and IDH2 mutations as prognostic indicators in nonpromyelocytic acute myeloid leukemia: a meta-analysis. Leuk Lymphom.
