Product Name :
GPR40 agonist 4
Description:
GPR40 agonist 4 is a potent free fatty acid receptor 1 (FFA1/ GPR40) agonist with a pEC50 of 7.54.
CAS:
2102196-57-4
Molecular Weight:
416.87
Formula:
C21H17ClO5S
Chemical Name:
2-[4-(2′-chloro-[1,1′-biphenyl]-3-ylmethoxy)benzenesulfonyl]acetic acid
Smiles :
OC(=O)CS(=O)(=O)C1C=CC(=CC=1)OCC1C=C(C=CC=1)C1=CC=CC=C1Cl
InChiKey:
YEFZZALZTNOYEA-UHFFFAOYSA-N
InChi :
InChI=1S/C21H17ClO5S/c22-20-7-2-1-6-19(20)16-5-3-4-15(12-16)13-27-17-8-10-18(11-9-17)28(25,26)14-21(23)24/h1-12H,13-14H2,(H,23,24)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
GPR40 agonist 4 is a potent free fatty acid receptor 1 (FFA1/ GPR40) agonist with a pEC50 of 7.54.|Product information|CAS Number: 2102196-57-4|Molecular Weight: 416.87|Formula: C21H17ClO5S|Chemical Name: 2-[4-(2′-chloro-[1,1′-biphenyl]-3-ylmethoxy)benzenesulfonyl]acetic acid|Smiles: OC(=O)CS(=O)(=O)C1C=CC(=CC=1)OCC1C=C(C=CC=1)C1=CC=CC=C1Cl|InChiKey: YEFZZALZTNOYEA-UHFFFAOYSA-N|InChi: InChI=1S/C21H17ClO5S/c22-20-7-2-1-6-19(20)16-5-3-4-15(12-16)13-27-17-8-10-18(11-9-17)28(25,26)14-21(23)24/h1-12H,13-14H2,(H,23,24)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 160 mg/mL (383.Chrysene-d12 Isotope-Labeled Compounds 81 mM; Need ultrasonic and warming).Gefitinib Protein Tyrosine Kinase/RTK |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32885741 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|GPR40 agonist 4 tends to have a low risk of activating caspase-3/7.|In Vivo:|Single oral administration of GPR40 agonist 4 (compound 20) robustly reduces the plasma glucose excursion and enhances insulin secretion during an oral glucose tolerance test (OGTT) in a dose-dependent manner from 1 to 10 mg/kg when GPR40 agonist 4 is dosed 60 min prior to the oral glucose challenge. The area under the curve of blood glucose (AUC0-120min) and blood insulin (AUC0-120min) reveal that the minimum effective dose of GPR40 agonist 4 is 3 mg/kg. The hyperglycemia state is also markedly improved in GPR40 agonist 4 (20 mg/kg) treated group.|Products are for research use only. Not for human use.|
