Product Name :
SB-423557
Description:
SB-423557 is an orally active calcium-sensing receptor (CaR) antagonist (IC50=520 nM), precursor of SB-423562 (IC50=73 nM). SB-423557 is well tolerated in human and increases plasma concentrations of exogenous parathyroid hormone (PTH) and stimulates bone formation.
CAS:
351490-26-1
Molecular Weight:
464.60
Formula:
C28H36N2O4
Chemical Name:
ethyl 3-[4-cyano-3-(3-{[1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]amino}-2-hydroxypropoxy)phenyl]propanoate
Smiles :
CCOC(=O)CCC1=CC(OCC(O)CNC(C)(C)CC2CC3=CC=CC=C3C2)=C(C=C1)C#N
InChiKey:
DMWBVRRUBDZTBK-UHFFFAOYSA-N
InChi :
InChI=1S/C28H36N2O4/c1-4-33-27(32)12-10-20-9-11-24(17-29)26(15-20)34-19-25(31)18-30-28(2,3)16-21-13-22-7-5-6-8-23(22)14-21/h5-9,11,15,21,25,30-31H,4,10,12-14,16,18-19H2,1-3H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
SB-423557 is an orally active calcium-sensing receptor (CaR) antagonist (IC50=520 nM), precursor of SB-423562 (IC50=73 nM). SB-423557 is well tolerated in human and increases plasma concentrations of exogenous parathyroid hormone (PTH) and stimulates bone formation.|Product information|CAS Number: 351490-26-1|Molecular Weight: 464.60|Formula: C28H36N2O4|Chemical Name: ethyl 3-[4-cyano-3-(3-{[1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]amino}-2-hydroxypropoxy)phenyl]propanoate|Smiles: CCOC(=O)CCC1=CC(OCC(O)CNC(C)(C)CC2CC3=CC=CC=C3C2)=C(C=C1)C#N|InChiKey: DMWBVRRUBDZTBK-UHFFFAOYSA-N|InChi: InChI=1S/C28H36N2O4/c1-4-33-27(32)12-10-20-9-11-24(17-29)26(15-20)34-19-25(31)18-30-28(2,3)16-21-13-22-7-5-6-8-23(22)14-21/h5-9,11,15,21,25,30-31H,4,10,12-14,16,18-19H2,1-3H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Palivizumab} site|{Palivizumab} Anti-infection|{Palivizumab} Epigenetics|{Palivizumab} Technical Information|{Palivizumab} References|{Palivizumab} custom synthesis} |Shelf Life: ≥12 months if stored properly.{{3,3′-Diindolylmethane} site|{3,3′-Diindolylmethane} Autophagy|{3,3′-Diindolylmethane} Biological Activity|{3,3′-Diindolylmethane} Formula|{3,3′-Diindolylmethane} supplier|{3,3′-Diindolylmethane} Epigenetics} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32940134 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|SB-423557 (oral administration; 10, 30 or 100 μM/kg; once daily; 12 weeks) elicits transient increases in plasma concentrations of PTH, resulting in increased bone mass and strength in both vertebrae and long bones compared to that of OVX controls.|Products are for research use only. Not for human use.|
