Product Name :
NS-2028
Description:
NS 2028 is a potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). It blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA (IC50 values are 17 and 20 nM respectively). NS 2028 also inhibits VEGF-induced cGMP accumulation.
CAS:
204326-43-2
Molecular Weight:
269.05
Formula:
C9H5BrN2O3
Chemical Name:
8-bromo-4H-[1, 2, 4]oxadiazolo[3, 4-c][1, 4]benzoxazin-1-one
Smiles :
O=C1ON=C2COC3=CC=C(Br)C=C3N21
InChiKey:
MUDRLQRJCGJJTB-UHFFFAOYSA-N
InChi :
InChI=1S/C9H5BrN2O3/c10-5-1-2-7-6(3-5)12-8(4-14-7)11-15-9(12)13/h1-3H,4H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
NS 2028 is a potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). It blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA (IC50 values are 17 and 20 nM respectively). NS 2028 also inhibits VEGF-induced cGMP accumulation.|Product information|CAS Number: 204326-43-2|Molecular Weight: 269.05|Formula: C9H5BrN2O3|Synonym:|NS 2028|NS2028|Chemical Name: 8-bromo-4H-[1, 2, 4]oxadiazolo[3, 4-c][1, 4]benzoxazin-1-one|Smiles: O=C1ON=C2COC3=CC=C(Br)C=C3N21|InChiKey: MUDRLQRJCGJJTB-UHFFFAOYSA-N|InChi: InChI=1S/C9H5BrN2O3/c10-5-1-2-7-6(3-5)12-8(4-14-7)11-15-9(12)13/h1-3H,4H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (929.{{Lopinavir} web|{Lopinavir} Metabolic Enzyme/Protease|{Lopinavir} Purity & Documentation|{Lopinavir} Purity|{Lopinavir} manufacturer|{Lopinavir} Epigenetics} 20 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{GSH/GSSG Assay Kit} MedChemExpress|{GSH/GSSG Assay Kit} TGF-beta/Smad|{GSH/GSSG Assay Kit} Technical Information|{GSH/GSSG Assay Kit} In Vitro|{GSH/GSSG Assay Kit} manufacturer} |Shelf Life: ≥12 months if stored properly.PMID:35126464 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|NS-2028 (10 μM; 24 hours) inhibits 25% cell number in comparation with those grown in the presence of vehicle[2]. NS-2028 (10 μM; 30 mins) attenuates VEGF-induced EC migration by inhibiting p38 MAPK activation[2].|In Vivo:|NS-2028 (Deliver orally; 1 g/L; 8 days) exhibits a significant reduction of new vessel formation in the avascular rabbit cornea in response to VEGF pellet implants[2].|References:|Olesen SP, et al. Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase. Br J Pharmacol. 1998 Jan;123(2):299-309.Morbidelli L, et al. The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability. Am J Physiol Regul Integr Comp Physiol. 2010 Mar;298(3):R824-32.Products are for research use only. Not for human use.|
