Product Name :
Azumolene
Description:
Azumolene is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum. Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor. Azumolene, an equipotent dantrolene analog, inhibits a component of SOCE coupled to activation of RyR1 by caffeine and ryanodine, whereas the SOCE component induced by thapsigargin is not affected.
CAS:
64748-79-4
Molecular Weight:
349.14
Formula:
C13H9BrN4O3
Chemical Name:
2,4-Imidazolidinedione, 1-(((5-(4-bromophenyl)-2-oxazolyl)methylene)amino)-
Smiles :
O=C1NC(=O)CN1N=CC1=NC=C(O1)C1C=CC(Br)=CC=1
InChiKey:
SEGCNGONCZQFDW-OMCISZLKSA-N
InChi :
InChI=1S/C13H9BrN4O3/c14-9-3-1-8(2-4-9)10-5-15-12(21-10)6-16-18-7-11(19)17-13(18)20/h1-6H,7H2,(H,17,19,20)/b16-6+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.{{Cosibelimab} medchemexpress|{Cosibelimab} PD-1/PD-L1|{Cosibelimab} Protocol|{Cosibelimab} Description|{Cosibelimab} custom synthesis|{Cosibelimab} Epigenetic Reader Domain}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Xylan} site|{Xylan} Metabolic Enzyme/Protease|{Xylan} Biological Activity|{Xylan} References|{Xylan} custom synthesis|{Xylan} Autophagy}
Additional information:
Azumolene is a muscle relaxant that inhibits the release of calcium from skeletal muscle sarcoplasmic reticulum. Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor. Azumolene, an equipotent dantrolene analog, inhibits a component of SOCE coupled to activation of RyR1 by caffeine and ryanodine, whereas the SOCE component induced by thapsigargin is not affected.|Product information|CAS Number: 64748-79-4|Molecular Weight: 349.14|Formula: C13H9BrN4O3|Synonym:|EU-4093|Azumolene|EU4093|EU 4093|Chemical Name: 2,4-Imidazolidinedione, 1-(((5-(4-bromophenyl)-2-oxazolyl)methylene)amino)-|Smiles: O=C1NC(=O)CN1N=CC1=NC=C(O1)C1C=CC(Br)=CC=1|InChiKey: SEGCNGONCZQFDW-OMCISZLKSA-N|InChi: InChI=1S/C13H9BrN4O3/c14-9-3-1-8(2-4-9)10-5-15-12(21-10)6-16-18-7-11(19)17-13(18)20/h1-6H,7H2,(H,17,19,20)/b16-6+|Technical Data|Appearance: Solid Power.PMID:24516446 |Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|References:|Thota S, Rodrigues DA, Pinheiro PSM, Lima LM, Fraga CAM, Barreiro EJ. N-Acylhydrazones as drugs. Bioorg Med Chem Lett. 2018 Sep 15;28(17):2797-2806. doi: 10.1016/j.bmcl.2018.07.015. Epub 2018 Jul 9. PMID: 30006065.Yarotskyy V, Protasi F, Dirksen RT. Accelerated activation of SOCE current in myotubes from two mouse models of anesthetic- and heat-induced sudden death. PLoS One. 2013 Oct 15;8(10):e77633. doi: 10.1371/journal.pone.0077633. PMID: 24143248; PMCID: PMC3797063.Products are for research use only. Not for human use.|
