Product Name :
TNFR1 Antibody
EN
Tumor necrosis factor receptor 1 Antibody
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Tumor necrosis factor receptor 1(TNFR1), a potent cytokine, elicits a broad spectrum of biologic responses which are mediated by binding to a cell surface receptor. Its gene is located on 12p13.2. The coding region and the 3-prime untranslated region of TNFR1 are distributed over 10 exons.1 There are 2 different proteins that serve as major receptors for TNF-alpha, one associated with myeloid cells and one associated with epithelial cells.2 Additionally, TNFR1 associates with the MADD protein through a death domain-death domain interaction. MADD provides a physical link between TNFR1 and the induction of mitogen-activated protein (MAP) kinase (e.g., ERK2) activation and arachidonic acid release.3 TNFR1-induced apoptosis involves 2 sequential signaling complexes. Complex I, the initial plasma membrane-bound complex, consists of TNFR1, the adaptor TRADD, the kinase RIP1, and TRAF2 and rapidly signals activation of NF-kappa-B. In a second step, TRADD and RIP1 associate with FADD and caspase-8, forming a cytoplasmic complex, complex II.4. PA000207-PA1210: TNFR1 Polyclonal Antibody Rabbit Polyclonal Antibody. Specificity/Sensitivity: Goat, human, mouse, rat. No cross reactivity with other proteins. Applications: WB 0.1-0.5 ug/ml IHC-P 0.5-1 ug/ml. Reactivity: Human. Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human TNFR1. Purification: Immunogen affinity purified. Form of Antibody: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3. Isotype: Rabbit IgG. Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
Additional Information:
|Background Tumor necrosis factor receptor 1(TNFR1), a potent cytokine, elicits a broad spectrum of biologic responses which are med by binding to a cell surface receptor. Its gene is located on 12p13.2. The coding region and the 3-prime untranslated region of TNFR1 are distributed over 10 exons.1 There are 2 different proteins that serve as major receptors for TNF-alpha, one assoc with myeloid cells and one assoc with epithel cells.2 Additionally, TNFR1 assoc with the MADD protein through a death domain-death domain interaction. MADD provides a physical link between TNFR1 and the induction of mitogen-activated protein (MAP) kinase (e.g., ERK2) activation and arachidonic acid release.3 TNFR1-induced apoptosis involves 2 sequent signaling complexes. Complex I, the init plasma membrane-bound complex, consists of TNFR1, the adaptor TRADD, the kinase RIP1, and TRAF2 and rapidly signals activation of NF-kap|Goat, human, mouse, rat. No cross reactivity with other proteins. Applications: WB 0.1-0.5 ug/ml IHC-P 0.5-1 ug/ml. Reactivity: Human. Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human TNFR1. Purification: Immunogen affinity purified. Form of Antibody: Each v contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3. Isotype: Rabbit IgG. Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original v after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
Related websites: https://www.medchemexpress.com/antibodies.html
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