TNF Receptor II Antibody

Additional Information:
|Background Tumor necrosis factor receptor 2 (TNFR2) is one of receptors of TNF. TNF has proinflammatory and immunosuppressive properties that may segregate at the level of the 2 TNF receptors (TNFRs), TNFR1 and TNFR2. The genes for TNFR1, a 55-kDa protein, and TNFR2, a 70-kDa protein, have been mapped to human chromosomes 12 (12pter-cen) and 1 (1pter-p32), respectively.1 TNFR2 was induced on glomerular endothel cells of nephritic kidneys, and TNFR2 expression on intrinsic cells, but not leukocytes, was essent for glomerulonephritis and glomerular complement deposition. TNFR1 promotes systemic immune responses and renal T cell death, while intrinsic cell TNFR2 plays a critical role in complement-dependent tissue injury. Therefore, therapeutic blockade specifically of TNFR2 may be a promising strategy in the treatment of immune-med glomerulonephritis.2 | TNFRII, CD120b Monoclonal Antibody Mouse Monoclonal Antibody. Specificity/Sensitivity: Anti-human tumour necrosis factor receptor II (TNFRII, CD120b). Applications: Indirect ELISA: 1 ug/ml as primary antibody. Reactivity: Human. Immunogen: Recombinant soluble human TNFRII-Fc fusion protein. Purification: purified from mouse ascites through a Protein A column. Form of Antibody: 1 ug/ml in PBS containing 0.1% sodium azide as a preservative. Clone No: KT30. Isotype: Mouse IgG2a. Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original v after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.