TAT-HyNic

Additional Information:
There is significant interest in the use of cationic peptides for the intracellular delivery of proteins, nucleic acids, siRNAs, or drugs into the cytoplasm of cells. Although the exact mode of action for these cell penetrating peptides (CPPs) has not been elucidated, their utility has been experimentally demonstrated for cytoplasmic drug delivery of therapeutic agents. Pre-activated PepLink CPPs contain our proprietary HyNiclinker for easy conjugation to other biomolecules. PepLink CPPs (with or without cleavable linkers) are readily conjugated to siRNAs or oligonucleotides for the study of targeted gene regulation. Often cell types respond differently to different classical cationic transfection agents so researchers routinely have to evaluate and optimize conditions for both efficient delivery and cytotoxic effects.