Product Name :
21-hydroxy Oligomycin A
Description:
21-hydroxy Oligomycin A is an antibiotic which was first isolated from S. cyaneogriseus ssp.noncyanogenus . 21-hydroxy Oligomycin A functions as μM inhibitor of the multidrug efflux pump P-gp, and low nM inhibitors of K-Ras PM localization . Cancer cell viability screening confirmed that 21-hydroxy Oligomycin A was cytotoxic to human colorectal carcinoma cells (IC50 > 3 μM), and was inhibitor of the ABC transporter efflux pump P-glyco-protein (P-gp). Significantly, 21-hydroxy Oligomycin A was exceptionally potent inhibitor of K-Ras PM localisation with Emax of 0.67–0.75 and an IC50 of 1.5–14 nM . 21-hydroxy Oligomycin A was inhibitor of K-Ras PM localisation in MDCK cell with an IC50 of 4.82 ± 0.70 nM. 21-hydroxy Oligomycin A was moderately cytotoxic towards both SW620 and SW620 Ad300 cells with the IC50 of 14.4 ± 0.6 and 11.8 ± 3.1 μM, respectively. In the flow cytometry assay, 21-hydroxy Oligomycin A (20 μM) increased intracellular calcein fluorescence significantly when compared with the negative control .
CAS:
102042-09-1
Molecular Weight:
807.06
Formula:
C45H74O12
Chemical Name:
(1R,5’S,6S,6’S,7R,8S,10R,11R,12S,14R,15S,16R,22S,23R,25S,27R,28S,29R)-22-ethyl-7,11,14,15,23-pentahydroxy-6′-[(2R)-2-hydroxypropyl]-5′,6,8,10,12,14,16,28,29-nonamethyl-2,26-dioxaspiro[bicyclo[23.3.1]nonacosane-27,2′-oxane]-4,18,20-triene-3,9,13-trione
Smiles :
C[C@@]1(O)[C@@H](O)[C@H](C)CC=CC=C[C@H](CC)[C@H](O)C[C@@H]2O[C@]3(CC[C@H](C)[C@H](C[C@@H](C)O)O3)[C@@H](C)[C@H](OC(=O)C=C[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@H](C)[C@@H](O)[C@H](C)C1=O)[C@@H]2C |t:8,10,38|
InChiKey:
SCVGLVGTMYJVOI-OBYFJLROSA-N
InChi :
InChI=1S/C45H74O12/c1-12-33-17-15-13-14-16-26(4)42(52)44(11,54)43(53)31(9)40(51)30(8)39(50)29(7)38(49)25(3)18-19-37(48)55-41-28(6)36(23-34(33)47)57-45(32(41)10)21-20-24(2)35(56-45)22-27(5)46/h13-15,17-19,24-36,38,40-42,46-47,49,51-52,54H,12,16,20-23H2,1-11H3/b14-13-,17-15-,19-18-/t24-,25-,26+,27+,28+,29-,30-,31-,32-,33-,34+,35-,36-,38+,40+,41+,42-,44+,45+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
21-hydroxy Oligomycin A is an antibiotic which was first isolated from S. cyaneogriseus ssp.noncyanogenus . 21-hydroxy Oligomycin A functions as μM inhibitor of the multidrug efflux pump P-gp, and low nM inhibitors of K-Ras PM localization .{{Olokizumab} medchemexpress|{Olokizumab} Immunology/Inflammation|{Olokizumab} Biological Activity|{Olokizumab} Data Sheet|{Olokizumab} manufacturer|{Olokizumab} Autophagy} Cancer cell viability screening confirmed that 21-hydroxy Oligomycin A was cytotoxic to human colorectal carcinoma cells (IC50 > 3 μM), and was inhibitor of the ABC transporter efflux pump P-glyco-protein (P-gp).{{Pioglitazone} medchemexpress|{Pioglitazone} PPAR|{Pioglitazone} Technical Information|{Pioglitazone} Formula|{Pioglitazone} custom synthesis|{Pioglitazone} Cancer} Significantly, 21-hydroxy Oligomycin A was exceptionally potent inhibitor of K-Ras PM localisation with Emax of 0.67–0.75 and an IC50 of 1.5–14 nM . 21-hydroxy Oligomycin A was inhibitor of K-Ras PM localisation in MDCK cell with an IC50 of 4.82 ± 0.70 nM. 21-hydroxy Oligomycin A was moderately cytotoxic towards both SW620 and SW620 Ad300 cells with the IC50 of 14.4 ± 0.6 and 11.8 ± 3.PMID:23903683 1 μM, respectively. In the flow cytometry assay, 21-hydroxy Oligomycin A (20 μM) increased intracellular calcein fluorescence significantly when compared with the negative control .|Product information|CAS Number: 102042-09-1|Molecular Weight: 807.06|Formula: C45H74O12|Chemical Name: (1R,5’S,6S,6’S,7R,8S,10R,11R,12S,14R,15S,16R,22S,23R,25S,27R,28S,29R)-22-ethyl-7,11,14,15,23-pentahydroxy-6′-[(2R)-2-hydroxypropyl]-5′,6,8,10,12,14,16,28,29-nonamethyl-2,26-dioxaspiro[bicyclo[23.3.1]nonacosane-27,2′-oxane]-4,18,20-triene-3,9,13-trione|Smiles: C[C@@]1(O)[C@@H](O)[C@H](C)CC=CC=C[C@H](CC)[C@H](O)C[C@@H]2O[C@]3(CC[C@H](C)[C@H](C[C@@H](C)O)O3)[C@@H](C)[C@H](OC(=O)C=C[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@H](C)[C@@H](O)[C@H](C)C1=O)[C@@H]2C |t:8,10,38||InChiKey: SCVGLVGTMYJVOI-OBYFJLROSA-N|InChi: InChI=1S/C45H74O12/c1-12-33-17-15-13-14-16-26(4)42(52)44(11,54)43(53)31(9)40(51)30(8)39(50)29(7)38(49)25(3)18-19-37(48)55-41-28(6)36(23-34(33)47)57-45(32(41)10)21-20-24(2)35(56-45)22-27(5)46/h13-15,17-19,24-36,38,40-42,46-47,49,51-52,54H,12,16,20-23H2,1-11H3/b14-13-,17-15-,19-18-/t24-,25-,26+,27+,28+,29-,30-,31-,32-,33-,34+,35-,36-,38+,40+,41+,42-,44+,45+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
