SNAP23 Antibody

Additional Information:
|Introduction SNAP23(Synaptosomal-Assoc Protein, 23-KD), also called SNAP23A, is a protein that in humans is encoded by the SNAP23 gene. The SNAP23 gene has 8 exons, with the init codon located in exon 2. The SNAP23 gene is mapped on 15q15.1-q15.2. The SNAP23 cDNA encodes a 211-amino acid polypeptide with a predicted mass of 23 kD. Its amino acid sequence is 59% identical to that of SNAP25. Northern blot analysis revealed that SNAP23 is ubiquitously expressed. SNAP23 is able to bind to multiple syntaxins as well as to multiple vesicle-assoc membrane proteins. After relocation, SNAP23 is required for exocytosis, implying a cruc role in promoting membrane fusion. TIVAMP-containing vesicles were concentrated in the apical domain of epithel cells. STX3A and SNAP23 were codistributed at the apical plasma membrane, where they formed N-ethyl maleimide-dependent SNARE complexes with TIVAMP and cellubrevin. SNAP23 is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essent component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. | SNAP23 Polyclonal Antibody Rabbit Polyclonal Antibody. Applications: WB 0.1-0.5 ug/ml; IHC-P 0.5-1 ug/ml; IHC-F 0.5-1 ug/ml. Reactivity: Human, Rat, Mouse. Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of human SNAP23, different from the related rat and mouse sequences by three amino acids . Purification: Immunogen affinity purified. Form of Antibody: Lyophilized. Isotype: Rabbit IgG. Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original v after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. |Other SNAP23 Antibody: Recombinant Human SNAP23 Protein