Shc1 Antibody

Additional Information:
|Introduction SHC1(SHC-transforming protein 1), also known as SHCA, is a protein that in humans is encoded by the SHC1 gene. SCOP classifies the 3D structure as belonging to the SH2 domain family. By Southern analysis of somatic cell hybrids followed by both isotopic and fluorescence in situ hybridization, Huebner et al. (1994) assigned the SHC1 gene to 1q21. Yulug et al. (1995) used fluorescence in situ hybridization to map the SHC1 gene to 1q21. By the same method, an SHC-related sequence (SHCL1) was mapped to 17q21-q22. By FISH analysis and direct sequencing of vectorette library PCR products, Harun et al. (1997) identified SHC1P1, a 3.2-kb processed pseudogene, in Xq12-q13.1. SHC1P1 is 85% identical to mouse Shc p66. Reporter assays showed FKHRL1 transactivates CAT, suggesting a ca|WB: 0.1-0.5 ug/ml IHC-P: 0.5-1 ug/ml. Reactivity: Human, Rat. Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of human SHC1, different from the related rat and mouse sequences by two amino acids. Purification: Immunogen affinity purified. Form of Antibody: Lyophilized. Reconstitution: 0.2 ml of distilled water will yield a concentration of 500 ug/ml. Isotype: Rabbit IgG. Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original v after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.