SCG3 Antibody

Background:
SCG3 (secretogranin ?) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Genetic variations in the SCG3 gene may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion. SCG3 was the only gene within a haplotype block that contained rs3764220. SCG3 mRNA and immunoreactivity were detected in the paraventricular nucleus, lateral hypothalamic area, and arcuate nucleus, and the protein coexisted with orexin, melanin-concentrating hormone, neuropeptide Y, and proopiomelanocortin. SCG3 formed a granule-like structure together with these neuropeptides. PA000223-PA1071: SCG3 Polyclonal Antibody Rabbit Polyclonal Antibody. Specificity/Sensitivity: Human, mouse, rat. No cross reactivity with other proteins. Applications: Western blot: At 1-2 ug/ml with the appropriate system to detect SCG3 in cells and tissues. Immunohistochemistry(P): At 0.5-1 ug/ml to detect SCG3 in formalin fixed and paraffin embedded tissues. Immunohistochemistry(F): At 0.5-1 ug/ml to detect SCG3 in formalin or acetone fixed tissues. Reactivity: Human, Mouse, Rat. Immunogen: A synthetic peptide corresponding to a sequence near the C-terminal of human SCG3, different from the related mouse and rat sequence by single amino acid. Purification: Immunogen affinity purified. Form of Antibody: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3. Isotype: Rabbit IgG. Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.