Product Name :
Gboxin
Description:
Gboxin is an oxidative phosphorylation (OXPHOS) inhibitor that targets glioblastoma. Gboxin inhibits the activity of F0F1 ATP synthase. Antitumour activity.
CAS:
2101315-36-8
Molecular Weight:
392.96
Formula:
C22H33ClN2O2
Chemical Name:
2-ethyl-3-methyl-1-(2-[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy-2-oxoethyl)-1H-1,3-benzodiazol-3-ium chloride
Smiles :
[Cl-].CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)CN1C(CC)=[N+](C)C2=CC=CC=C12
InChiKey:
UBWVTCCKVGOTBG-VYZBTARASA-M
InChi :
InChI=1S/C22H33N2O2.ClH/c1-6-21-23(5)18-9-7-8-10-19(18)24(21)14-22(25)26-20-13-16(4)11-12-17(20)15(2)3;/h7-10,15-17,20H,6,11-14H2,1-5H3;1H/q+1;/p-1/t16-,17+,20-;/m1./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Gboxin is an oxidative phosphorylation (OXPHOS) inhibitor that targets glioblastoma. Gboxin inhibits the activity of F0F1 ATP synthase. Antitumour activity.|Product information|CAS Number: 2101315-36-8|Molecular Weight: 392.96|Formula: C22H33ClN2O2|Chemical Name: 2-ethyl-3-methyl-1-(2-[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy-2-oxoethyl)-1H-1,3-benzodiazol-3-ium chloride|Smiles: [Cl-].Cosibelimab Protocol CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)CN1C(CC)=[N+](C)C2=CC=CC=C12|InChiKey: UBWVTCCKVGOTBG-VYZBTARASA-M|InChi: InChI=1S/C22H33N2O2.Clemizole MedChemExpress ClH/c1-6-21-23(5)18-9-7-8-10-19(18)24(21)14-22(25)26-20-13-16(4)11-12-17(20)15(2)3;/h7-10,15-17,20H,6,11-14H2,1-5H3;1H/q+1;/p-1/t16-,17+,20-;/m1.PMID:32424550 /s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 32.5 mg/mL (82.71 mM; Need ultrasonic). H2O : 10 mg/mL (25.45 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Gboxin (0-15 μM; 96 hours) specifically inhibit the growth of primary ‘high-throughput GBM sphere’ (HTS) cells but not that of cycling primary low-passage mouse embryonic fibroblasts (MEFs) or astrocytes.|Products are for research use only. Not for human use.|
