Product Name :
TC-N 22A
Description:
TC-N 22A is a potent, selective, orally active and brain-permeable mGlu4 PAM with an EC50 of 9 nM in human mGlu4-expressing BHK cells. TC-N 22A is less active (EC50>10 μM) in agonist and PAM model at mGlu 1, 2, 3, 5, and 7 receptors. TC-N 22A has the potential for research of CNS disease in vivo.
CAS:
1314140-00-5
Molecular Weight:
283.35
Formula:
C14H13N5S
Chemical Name:
(4Z)-N-(pyridin-2-yl)-5-thia-3,11,12-triazatricyclo[8.3.0.0²,⁶]trideca-1(13),2(6),10-trien-4-imine
Smiles :
C1CCC2=NNC=C2C2N/C(=N/C3=CC=CC=N3)/SC=21
InChiKey:
DBISXWCOHGUFSF-UHFFFAOYSA-N
InChi :
InChI=1S/C14H13N5S/c1-2-7-15-12(6-1)17-14-18-13-9-8-16-19-10(9)4-3-5-11(13)20-14/h1-2,6-8H,3-5H2,(H,16,19)(H,15,17,18)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Altretamine manufacturer
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
TC-N 22A is a potent, selective, orally active and brain-permeable mGlu4 PAM with an EC50 of 9 nM in human mGlu4-expressing BHK cells. TC-N 22A is less active (EC50>10 μM) in agonist and PAM model at mGlu 1, 2, 3, 5, and 7 receptors. TC-N 22A has the potential for research of CNS disease in vivo.|Product information|CAS Number: 1314140-00-5|Molecular Weight: 283.35|Formula: C14H13N5S|Chemical Name: (4Z)-N-(pyridin-2-yl)-5-thia-3,11,12-triazatricyclo[8.3.0.0²,⁶]trideca-1(13),2(6),10-trien-4-imine|Smiles: C1CCC2=NNC=C2C2N/C(=N/C3=CC=CC=N3)/SC=21|InChiKey: DBISXWCOHGUFSF-UHFFFAOYSA-N|InChi: InChI=1S/C14H13N5S/c1-2-7-15-12(6-1)17-14-18-13-9-8-16-19-10(9)4-3-5-11(13)20-14/h1-2,6-8H,3-5H2,(H,16,19)(H,15,17,18)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.Streptonigrin Protocol |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32856591 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|TC-N 22A is selected for mGlu4 and has an EC50 of 9 nM in human mGlu4-expressing BHK cells. This compound is less active in agonist and PAM modelinactive (EC50>10 μM), and is inactive in negative allosteric modulator (NAM) model at mGlu 1, 2, 3, 5, and 7 receptors (IC50 >10 μM) and shows low potential for hERG channel inhibition.|In Vivo:|TC-N 22A (oral administration; 10 mg/kg) displays good plasma (259 ng/mL) and brain exposure levels (200 ng/mL) as well as good brain penetration (brain/plasma ratios of 0.8) after 1 h following a 10 mg/kg oral administration in SpragueDawley rats.|Products are for research use only. Not for human use.|
