Product Name :
(Rac)-VU 6008667
Description:
(Rac)-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) (IC50=1.8 μM, pIC50= 5.75), has high CNS penetration.
CAS:
2092917-63-8
Molecular Weight:
438.85
Formula:
C24H17ClF2N2O2
Chemical Name:
9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1H,2H,3H,5H,9bH-imidazo[2,1-a]isoindol-5-one
Smiles :
CC1=CC(=CC=C1Cl)C12C3C=CC=CC=3C(=O)N1CCN2C(=O)C1C=C(F)C(F)=CC=1
InChiKey:
XMSLRELXMCKGCB-UHFFFAOYSA-N
InChi :
InChI=1S/C24H17ClF2N2O2/c1-14-12-16(7-8-19(14)25)24-18-5-3-2-4-17(18)23(31)29(24)11-10-28(24)22(30)15-6-9-20(26)21(27)13-15/h2-9,12-13H,10-11H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
(Rac)-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) (IC50=1.8 μM, pIC50= 5.75), has high CNS penetration.|Product information|CAS Number: 2092917-63-8|Molecular Weight: 438.85|Formula: C24H17ClF2N2O2|Chemical Name: 9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1H,2H,3H,5H,9bH-imidazo[2,1-a]isoindol-5-one|Smiles: CC1=CC(=CC=C1Cl)C12C3C=CC=CC=3C(=O)N1CCN2C(=O)C1C=C(F)C(F)=CC=1|InChiKey: XMSLRELXMCKGCB-UHFFFAOYSA-N|InChi: InChI=1S/C24H17ClF2N2O2/c1-14-12-16(7-8-19(14)25)24-18-5-3-2-4-17(18)23(31)29(24)11-10-28(24)22(30)15-6-9-20(26)21(27)13-15/h2-9,12-13H,10-11H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (284.Clarithromycin In Vitro 84 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Pimavanserin Epigenetic Reader Domain |Shelf Life: ≥12 months if stored properly.PMID:31774314 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359.Products are for research use only. Not for human use.|
