Product Name :
Isoforskolin
Description:
Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely TNF-α, IL-1β, IL-6 and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis.
CAS:
64657-21-2
Molecular Weight:
410.50
Formula:
C22H34O7
Chemical Name:
(3R, 4aR, 5S, 6S, 6aS, 10S, 10aR, 10bS)-3-ethenyl-5, 10, 10b-trihydroxy-3, 4a, 7, 7, 10a-pentamethyl-1-oxo-dodecahydro-1H-naphtho[2, 1-b]pyran-6-yl acetate
Smiles :
CC1(C)CC[C@H](O)[C@@]2(C)[C@H]1[C@H](OC(C)=O)[C@H](O)[C@@]1(C)O[C@](C)(CC(=O)[C@@]12O)C=C
InChiKey:
CLOQVZCSBYBUPB-KGGHGJDLSA-N
InChi :
InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(28-12(2)23)17(26)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely TNF-α, IL-1β, IL-6 and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis.|Product information|CAS Number: 64657-21-2|Molecular Weight: 410.50|Formula: C22H34O7|Synonym:|Coleonol B|Chemical Name: (3R, 4aR, 5S, 6S, 6aS, 10S, 10aR, 10bS)-3-ethenyl-5, 10, 10b-trihydroxy-3, 4a, 7, 7, 10a-pentamethyl-1-oxo-dodecahydro-1H-naphtho[2, 1-b]pyran-6-yl acetate|Smiles: CC1(C)CC[C@H](O)[C@@]2(C)[C@H]1[C@H](OC(C)=O)[C@H](O)[C@@]1(C)O[C@](C)(CC(=O)[C@@]12O)C=C|InChiKey: CLOQVZCSBYBUPB-KGGHGJDLSA-N|InChi: InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(28-12(2)23)17(26)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Thio-TEPA web |Shelf Life: ≥360 days if stored properly.NY-ESO-1 (157-165) peptide Formula |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:31565905 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Isoforskolin downregulates the transcription and expression of TNF-α and IL-6 induced by recombinant Borrelia burgdorferi basic membrane protein A (rBmpA).|References:|Zhao H, et al. Isoforskolin downregulates proinflammatory responses induced by Borrelia burgdorferi basic membrane protein A.Exp Ther Med. 2017 Dec;14(6):5974-5980.Products are for research use only. Not for human use.|
