Product Name :
[R112A, R113G]Brain derived neurotrophic factor precursor (mouse), (recombinant)
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≥99%
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Description:
Trk ligand BDNF is a neurotrophic factor expressed by proteolytic cleavage of its precursor, proBDNF. The precursor form was thought to be important for the correct folding, secretion and trafficking of the mature protein. Processes such as neuronal process retraction and neuronal apoptosis were thought to be mediated by the binding of BDNF to p75.{{7196-71-6} site|{7196-71-6} Biological Activity|{7196-71-6} Data Sheet|{7196-71-6} custom synthesis} The finding that proBDNF, and not mature BDNF, is the preferred ligand for p756 has led to a reexamination of the biological roles of the two forms.{{202668-42-6} MedChemExpress|{202668-42-6} Technical Information|{202668-42-6} Data Sheet|{202668-42-6} manufacturer} The amino acid sequence of proBDNF-mut has been changed to prevent the proteolytic cleavage which results in the formation of mature BDNF.PMID:31335083
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Additional Information :
| Alternative Name pro-BDNF | Application Notes Can be used as growth and differentiation factor for neuronal cultures and for receptor binding studies. | Purity ≥99% | Source Produced in E. coli. | UniProt ID P21237
