Product Name :
CMPD1
Description:
CMPD1 is a selective and non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor with apparent Ki (Kiapp) of 330 nM.
CAS:
41179-33-3
Molecular Weight:
349.40
Formula:
C22H20FNO2
Chemical Name:
4-{2′-fluoro-[1, 1′-biphenyl]-4-yl}-N-(4-hydroxyphenyl)butanamide
Smiles :
OC1C=CC(=CC=1)NC(=O)CCCC1C=CC(=CC=1)C1=CC=CC=C1F
InChiKey:
ODYAQBDIXCVKAE-UHFFFAOYSA-N
InChi :
InChI=1S/C22H20FNO2/c23-21-6-2-1-5-20(21)17-10-8-16(9-11-17)4-3-7-22(26)24-18-12-14-19(25)15-13-18/h1-2,5-6,8-15,25H,3-4,7H2,(H,24,26)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CMPD1 is a selective and non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor with apparent Ki (Kiapp) of 330 nM.|Product information|CAS Number: 41179-33-3|Molecular Weight: 349.{{Phenylbutyrate} site|{Phenylbutyrate} Epigenetics|{Phenylbutyrate} Purity & Documentation|{Phenylbutyrate} Formula|{Phenylbutyrate} manufacturer|{Phenylbutyrate} Epigenetic Reader Domain} 40|Formula: C22H20FNO2|Chemical Name: 4-{2′-fluoro-[1, 1′-biphenyl]-4-yl}-N-(4-hydroxyphenyl)butanamide|Smiles: OC1C=CC(=CC=1)NC(=O)CCCC1C=CC(=CC=1)C1=CC=CC=C1F|InChiKey: ODYAQBDIXCVKAE-UHFFFAOYSA-N|InChi: InChI=1S/C22H20FNO2/c23-21-6-2-1-5-20(21)17-10-8-16(9-11-17)4-3-7-22(26)24-18-12-14-19(25)15-13-18/h1-2,5-6,8-15,25H,3-4,7H2,(H,24,26)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (286.{{Opipramol} medchemexpress|{Opipramol} Sigma Receptor|{Opipramol} Technical Information|{Opipramol} Data Sheet|{Opipramol} supplier|{Opipramol} Autophagy} 20 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32886033 |Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CMPD1 does not inhibit p38 MAPK-mediated phosphorylation of other two substrates, MBP and ATF2. CMPD1 induced mitotic arrest and apoptosis in U87 cells. CMPD1 inhibits tubulin polymerisation in glioblastoma cells.|References:|Gurgis F, et al. Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2. Cell Death Discov. 2015 Sep 7;1:15028.Davidson W, er al. Discovery and characterization of a substrate selective p38alpha inhibitor. Biochemistry. 2004 Sep 21;43(37):11658-71.Phoa AF, et al. Pharmacology of novel small-molecule tubulin inhibitors in glioblastoma cells with enhanced EGFR signalling. Biochem Pharmacol. 2015 Dec 15;98(4):587-601.Products are for research use only. Not for human use.|
