Product Name :
tCFA15
Description:
tCFA15 is a trimethyl cyclohexenonic long chain fatty alcohol containing 15 carbon atoms on the side chain, promotes the differentiation of neurons, and may regulates Notch signaling.
CAS:
220757-88-0
Molecular Weight:
364.60
Formula:
C24H44O2
Chemical Name:
3-(15-hydroxypentadecyl)-2, 4, 4-trimethylcyclohex-2-en-1-one
Smiles :
CC1C(=O)CCC(C)(C)C=1CCCCCCCCCCCCCCCO
InChiKey:
FGMAOXGOTRUOKJ-UHFFFAOYSA-N
InChi :
InChI=1S/C24H44O2/c1-21-22(24(2,3)19-18-23(21)26)17-15-13-11-9-7-5-4-6-8-10-12-14-16-20-25/h25H,4-20H2,1-3H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
tCFA15 is a trimethyl cyclohexenonic long chain fatty alcohol containing 15 carbon atoms on the side chain, promotes the differentiation of neurons, and may regulates Notch signaling.|Product information|CAS Number: 220757-88-0|Molecular Weight: 364.60|Formula: C24H44O2|Chemical Name: 3-(15-hydroxypentadecyl)-2, 4, 4-trimethylcyclohex-2-en-1-one|Smiles: CC1C(=O)CCC(C)(C)C=1CCCCCCCCCCCCCCCO|InChiKey: FGMAOXGOTRUOKJ-UHFFFAOYSA-N|InChi: InChI=1S/C24H44O2/c1-21-22(24(2,3)19-18-23(21)26)17-15-13-11-9-7-5-4-6-8-10-12-14-16-20-25/h25H,4-20H2,1-3H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 130 mg/mL (356.{{Nateglinide} medchemexpress|{Nateglinide} Potassium Channel|{Nateglinide} Protocol|{Nateglinide} Description|{Nateglinide} custom synthesis|{Nateglinide} Autophagy} 56 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Recombinant Murine Interleukin-6} MedChemExpress|{Recombinant Murine Interleukin-6} Biological Activity|{Recombinant Murine Interleukin-6} Formula|{Recombinant Murine Interleukin-6} manufacturer|{Recombinant Murine Interleukin-6} Autophagy} |Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32851919 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|tCFA15 (10 nM-1 μM) dose-dependently affects the differentiation of neural stem cell-derived neurospheres by promoting neurons at the expense of astrocytes, and such effect is via Notch1. tCFA15 (1 μM) specifically decreases the level of Notch1 mRNA in spheres, and such an effect is also observed in decreases Notch1 expression in neuronal and glial cell cultures. tCFA15 stimulates arginine vasopressin secretion in nerve terminals of the neurohypophysis.|References:|Bouissac J, et al. tCFA15, a trimethyl cyclohexenonic long-chain fatty alcohol, affects neural stem fate and differentiation by modulating Notch1 activity. Eur J Pharmacol. 2013 Oct 15;718(1-3):383-92.Girlanda-Junges C, et al. 3-(15-Hydroxypentadecyl)-2,4,4-trimethyl-2-cyclohexen-1-one and its effect on neuropeptide secretion. Bioorg Med Chem Lett. 2000 Nov 20;10(22):2537-9.Products are for research use only. Not for human use.|
