Product Name :
Anti-Human IgG, AlpSdAbs® VHH(VcMMAF ×4)
Applications:
Internalization Test
Reactivity :
Human IgG
Conjugate:
VcMMAF
Advantages :
High lot-to-lot consistencyIncreased sensitivity and higher affinityAnimal-free production
Description:
| Description: Anti-Human IgG, AlpSdAbs® VHH(VcMMAF ×4) is designed for studying on the internalization of antibodies. Anti-Human IgG, AlpSdAbs® VHH(VcMMAF ×4) is based on monoclonal, recombinant single domain antibody to human IgG Fc coupled to VcMMAF. Based on immunoelectrophoresis and/or ELISA, Anti-Human IgG, AlpSdAbs® VHH(VcMMAF ×4) reacts with the Fc fragment of human IgG heavy chain but not with the Fab portion of human IgG. Anti-Human IgG, AlpSdAbs® VHH(VcMMAF ×4) is an effective detection tool and can be used as a useful tool for the evaluation of antibody potency prior to ADCs. | Immunogen: Recombinant Fc region of human IgG | Host: Alpaca pacous | Isotype: VHH domain of alpaca IgG2b/2c | Conjugate: VcMMAF(2 moles VcMMAF per mole VHH) | Specificity: Human IgG(Fcγ fragment specific), including IgG1, IgG2, IgG3, IgG4 and their mutations(LALA or YTE) | Cross-Reactivity: Recognizes human IgG Fcγ fragment specifically, and reacts with cynomolgus IgG. No Cross-reactivity to rabbit , mouse, rat, goat IgG | Purity: Recombinant Expression and Affinity purified | Concentration: 0.5mg/ml | Formation: Liquid, 10mM PBS (pH 7.4) | Storage: Store at –20 °C(Avoid freeze / thaw cycles) | Background:VHH are single-domain antibodies derived from the variable regions of heavy chain of Camelidae immunoglobulin. The size of VHH is extremely small(
Description2 :
Anti-Human IgG, AlpSdAbs® VHH(VcMMAF ×4) is designed for studying on the internalization of antibodies. Anti-Human IgG, AlpSdAbs® VHH(VcMMAF ×4) is based on monoclonal, recombinant single domain antibody to human IgG Fc coupled to VcMMAF.{{185243-69-0} web|{185243-69-0} Purity & Documentation|{185243-69-0} References|{185243-69-0} supplier} Based on immunoelectrophoresis and/or ELISA, Anti-Human IgG, AlpSdAbs® VHH(VcMMAF ×4) reacts with the Fc fragment of human IgG heavy chain but not with the Fab portion of human IgG.{{2750709-91-0} web|{2750709-91-0} Biological Activity|{2750709-91-0} References|{2750709-91-0} manufacturer} Anti-Human IgG, AlpSdAbs® VHH(VcMMAF ×4) is an effective detection tool and can be used as a useful tool for the evaluation of antibody potency prior to ADCs.PMID:30725725
Immunogen:
Recombinant Fc region of human IgG
Host :
Alpaca pacous
Isotype:
VHH domain of alpaca IgG2b/2c
Purity :
Recombinant Expression and Affinity purified
Buffer :
Storage :
Store at –20 °C(Avoid freeze / thaw cycles)
Function:
Antibody Internalization Test: 2ug per 10ug test antibody(molar ratio=2:1).Dilution factors are presented in the form of a range because the optimal dilution is a function of many factors, such as antigen density, permeability, etc. The actual dilution used must be determined empirically.
