Product Name :
CP21R7
Description:
CP21R7 is potent GSK-3β inhibitor, with an IC50 of 1.8 nM; CP21R7 also shows inhibitory activitiy against PKCα, with an IC50 of 1900 nM.
CAS:
125314-13-8
Molecular Weight:
317.34
Formula:
C19H15N3O2
Chemical Name:
3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-2, 5-dihydro-1H-pyrrole-2, 5-dione
Smiles :
CN1C=C(C2=C(C3=CC(N)=CC=C3)C(=O)NC2=O)C2=CC=CC=C12
InChiKey:
RGTAEYDIDMGJLX-UHFFFAOYSA-N
InChi :
InChI=1S/C19H15N3O2/c1-22-10-14(13-7-2-3-8-15(13)22)17-16(18(23)21-19(17)24)11-5-4-6-12(20)9-11/h2-10H,20H2,1H3,(H,21,23,24)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Tropisetron} site|{Tropisetron} Neuronal Signaling|{Tropisetron} Purity & Documentation|{Tropisetron} In Vitro|{Tropisetron} supplier|{Tropisetron} Autophagy}
Additional information:
CP21R7 is potent GSK-3β inhibitor, with an IC50 of 1.{{Eltoprazine} medchemexpress|{Eltoprazine} Modulator|{Eltoprazine} Activator|{Eltoprazine} Purity & Documentation|{Eltoprazine} References|{Eltoprazine} manufacturer} 8 nM; CP21R7 also shows inhibitory activitiy against PKCα, with an IC50 of 1900 nM.|Product information|CAS Number: 125314-13-8|Molecular Weight: 317.34|Formula: C19H15N3O2|Synonym:|CP21|Chemical Name: 3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-2, 5-dihydro-1H-pyrrole-2, 5-dione|Smiles: CN1C=C(C2=C(C3=CC(N)=CC=C3)C(=O)NC2=O)C2=CC=CC=C12|InChiKey: RGTAEYDIDMGJLX-UHFFFAOYSA-N|InChi: InChI=1S/C19H15N3O2/c1-22-10-14(13-7-2-3-8-15(13)22)17-16(18(23)21-19(17)24)11-5-4-6-12(20)9-11/h2-10H,20H2,1H3,(H,21,23,24)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 32 mg/mL (100.84 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32552230 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CP21R7 (Compound 9) is a selective inhibitor of GSK-3β, with an IC50 of 1.8 nM; the IC50 of CP21R7 against PKCα is 1900 nM. CP21R7 (CP21, 3 μM) potently activates canonical Wnt signaling with highest activity. CP21 significantly increases total levels of intracellular β-catenin. CP21 combined with BMP4 induces commitment of hPSCs towards mesoderm.|References:|Gong L, et al. Discovery of potent and bioavailable GSK-3beta inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1693-6.Patsch C, et al. Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nat Cell Biol. 2015 Aug;17(8):994-1003.Products are for research use only. Not for human use.|
