Product Name :
Brevilin A
Description:
Brevilin A is a sesquiterpene lactone isolated from Centipeda minima with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 µM) in Cancer Cells. Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.
CAS:
16503-32-5
Molecular Weight:
346.42
Formula:
C20H26O5
Chemical Name:
(3S, 3aR, 4S, 4aR, 7aR, 8R, 9aR)-3, 4a, 8-trimethyl-2, 5-dioxo-2H, 3H, 3aH, 4H, 4aH, 5H, 7aH, 8H, 9H, 9aH-azuleno[6, 5-b]furan-4-yl (2Z)-2-methylbut-2-enoate
Smiles :
C/C(=C/C)/C(=O)O[C@H]1[C@H]2[C@@H](C[C@@H](C)[C@@H]3C=CC(=O)[C@@]13C)OC(=O)[C@H]2C
InChiKey:
KUPPZVXLWANEJJ-UXPPPGSFSA-N
InChi :
InChI=1S/C20H26O5/c1-6-10(2)18(22)25-17-16-12(4)19(23)24-14(16)9-11(3)13-7-8-15(21)20(13,17)5/h6-8,11-14,16-17H,9H2,1-5H3/b10-6-/t11-,12+,13+,14-,16-,17+,20+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Brevilin A is a sesquiterpene lactone isolated from Centipeda minima with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 µM) in Cancer Cells. Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.|Product information|CAS Number: 16503-32-5|Molecular Weight: 346.42|Formula: C20H26O5|Chemical Name: (3S, 3aR, 4S, 4aR, 7aR, 8R, 9aR)-3, 4a, 8-trimethyl-2, 5-dioxo-2H, 3H, 3aH, 4H, 4aH, 5H, 7aH, 8H, 9H, 9aH-azuleno[6, 5-b]furan-4-yl (2Z)-2-methylbut-2-enoate|Smiles: C/C(=C/C)/C(=O)O[C@H]1[C@H]2[C@@H](C[C@@H](C)[C@@H]3C=CC(=O)[C@@]13C)OC(=O)[C@H]2C|InChiKey: KUPPZVXLWANEJJ-UXPPPGSFSA-N|InChi: InChI=1S/C20H26O5/c1-6-10(2)18(22)25-17-16-12(4)19(23)24-14(16)9-11(3)13-7-8-15(21)20(13,17)5/h6-8,11-14,16-17H,9H2,1-5H3/b10-6-/t11-,12+,13+,14-,16-,17+,20+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (288.{{SNPB} web|{SNPB} Antibody-drug Conjugate/ADC Related|{SNPB} Biological Activity|{SNPB} Formula|{SNPB} manufacturer|{SNPB} Autophagy} 67 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Modakafusp alfa} MedChemExpress|{Modakafusp alfa} Immunology/Inflammation|{Modakafusp alfa} Biological Activity|{Modakafusp alfa} In Vivo|{Modakafusp alfa} manufacturer|{Modakafusp alfa} Epigenetics} |Shelf Life: ≥360 days if stored properly.PMID:32875978 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Chen X, et al. Brevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells. PLoS One. 2013 May 21;8(5):e63697.You P, et al. Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation. Biomed Pharmacother. 2018 Feb;98:619-625.Products are for research use only. Not for human use.|
