Product Name :
SNIPER(ABL)-015
Description:
SNIPER(ABL)-015, conjugating GNF5 (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 5 μM .
CAS:
Molecular Weight:
1094.23
Formula:
C58H70F3N9O9
Chemical Name:
(2S)-2-{[(2S)-1-[(2S)-2-cyclohexyl-2-[(2S)-2-(methylamino)propanamido]acetyl]pyrrolidin-2-yl]formamido}-3, 3-diphenyl-N-(2-{2-[2-(2-{[3-(6-{[4-(trifluoromethoxy)phenyl]amino}pyrimidin-4-yl)phenyl]formamido}ethoxy)ethoxy]ethoxy}ethyl)propanamide
Smiles :
C[C@H](NC)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C1C=CC=CC=1)C1C=CC=CC=1)C(=O)NCCOCCOCCOCCNC(=O)C1=CC(=CC=C1)C1=CC(NC2C=CC(=CC=2)OC(F)(F)F)=NC=N1
InChiKey:
CYNNYMZGPVIXHI-ZUDXTMBRSA-N
InChi :
InChI=1S/C58H70F3N9O9/c1-39(62-2)53(71)68-51(42-18-10-5-11-19-42)57(75)70-29-13-22-48(70)55(73)69-52(50(40-14-6-3-7-15-40)41-16-8-4-9-17-41)56(74)64-28-31-77-33-35-78-34-32-76-30-27-63-54(72)44-21-12-20-43(36-44)47-37-49(66-38-65-47)67-45-23-25-46(26-24-45)79-58(59,60)61/h3-4,6-9,12,14-17,20-21,23-26,36-39,42,48,50-52,62H,5,10-11,13,18-19,22,27-35H2,1-2H3,(H,63,72)(H,64,74)(H,68,71)(H,69,73)(H,65,66,67)/t39-,48-,51-,52-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{SNPB} web|{SNPB} Antibody-drug Conjugate/ADC Related|{SNPB} Biological Activity|{SNPB} Purity|{SNPB} supplier|{SNPB} Autophagy}
Shelf Life:
≥12 months if stored properly.{{ALZ-801} MedChemExpress|{ALZ-801} Amyloid-β|{ALZ-801} Technical Information|{ALZ-801} In Vitro|{ALZ-801} custom synthesis|{ALZ-801} Cancer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
SNIPER(ABL)-015, conjugating GNF5 (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 5 μM .|Product information|Molecular Weight: 1094.23|Formula: C58H70F3N9O9|Chemical Name: (2S)-2-{[(2S)-1-[(2S)-2-cyclohexyl-2-[(2S)-2-(methylamino)propanamido]acetyl]pyrrolidin-2-yl]formamido}-3, 3-diphenyl-N-(2-{2-[2-(2-{[3-(6-{[4-(trifluoromethoxy)phenyl]amino}pyrimidin-4-yl)phenyl]formamido}ethoxy)ethoxy]ethoxy}ethyl)propanamide|Smiles: C[C@H](NC)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C1C=CC=CC=1)C1C=CC=CC=1)C(=O)NCCOCCOCCOCCNC(=O)C1=CC(=CC=C1)C1=CC(NC2C=CC(=CC=2)OC(F)(F)F)=NC=N1|InChiKey: CYNNYMZGPVIXHI-ZUDXTMBRSA-N|InChi: InChI=1S/C58H70F3N9O9/c1-39(62-2)53(71)68-51(42-18-10-5-11-19-42)57(75)70-29-13-22-48(70)55(73)69-52(50(40-14-6-3-7-15-40)41-16-8-4-9-17-41)56(74)64-28-31-77-33-35-78-34-32-76-30-27-63-54(72)44-21-12-20-43(36-44)47-37-49(66-38-65-47)67-45-23-25-46(26-24-45)79-58(59,60)61/h3-4,6-9,12,14-17,20-21,23-26,36-39,42,48,50-52,62H,5,10-11,13,18-19,22,27-35H2,1-2H3,(H,63,72)(H,64,74)(H,68,71)(H,69,73)(H,65,66,67)/t39-,48-,51-,52-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32796419 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.Products are for research use only. Not for human use.|
