Product Name :
Anti-TNFRSF10B, Human antibody
Applications:
ELISA,Flow Cyt
Reactivity :
Human
Conjugate:
Unconjugated
Advantages :
High lot-to-lot consistencyIncreased sensitivity and higher affinityAnimal-free production
Description:
| Description: Anti-TNFRSF10B, Human antibody is designed for detecting human TNFRSF10B specifically. Based on ELISA and/or FCM, Anti-TNFRSF10B, Human antibody reacts with human TNFRSF10B specifically. | Immunogen: Recombinant human TNFRSF10B | Host: Alpaca pacous | Isotype: Human IgG1 | Conjugate: Unconjugated | Specificity: Human TNFRSF10B | Purity: Recombinant Expression and Affinity purified | Concentration: 1mg/ml | Formation: Liquid, 10mM PBS (pH 7.5), 0.05% sucrose, 0.1% trehalose, 0.01% proclin300, 50% Glycerol | Storage: Store at –20 °C, (Avoid freeze / thaw cycles) | Background:DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a recently identified death domain containing receptor for TRAIL, which mediates TRAIL induced apoptosis. DR5 is a member of the TNF-receptor superfamily, and contains an intracellular death domain. DR5 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by DR5. Two transcript variants encoding different isoforms of DR5 and one non-coding transcript have been found. Overexpression of DR5 induces apoptosis and activates NF-kappa-B. DR5 is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. Diseases associated with DR5 dysfunction include squamous cell carcinoma, and diffuse infiltrative lymphocytosis syndrome.
Description2 :
Anti-TNFRSF10B, Human antibody is designed for detecting human TNFRSF10B specifically.{{2887480-87-5} medchemexpress|{2887480-87-5} Protocol|{2887480-87-5} In Vitro|{2887480-87-5} custom synthesis} Based on ELISA and/or FCM, Anti-TNFRSF10B, Human antibody reacts with human TNFRSF10B specifically.{{540737-29-9} site|{540737-29-9} Purity & Documentation|{540737-29-9} References|{540737-29-9} custom synthesis}
Immunogen:
Recombinant human TNFRSF10B
Host :
Alpaca pacous
Isotype:
Human IgG1
Purity :
Recombinant Expression and Affinity purified
Buffer :
Storage :
Store at –20 °C, (Avoid freeze / thaw cycles)
Function:
ELISA: 1:4,000-1:10000Flow Cytometry：1:200-1:1000Dilution factors are presented in the form of a range because the optimal dilution is a function of many factors, such as antigen density, permeability, etc.PMID:30855902 The actual dilution used must be determined empirically.
