Product Name :
Anti-PDL1, Human antibody
Applications:
ELISA,Flow Cyt
Reactivity :
Human/Cynomolgus
Conjugate:
Unconjugated
Advantages :
High lot-to-lot consistencyIncreased sensitivity and higher affinityAnimal-free production
Description:
| Description: Anti-PDL1, Human antibody is designed for detecting human PDL1 specifically. Anti-PDL1, Human antibody is recombinant VHH domain of alpaca IgG2b/2c fused to Human IgG1 Fc. Based on ELISA, Anti-PDL1, Human antibody reacts with human PDL1, and has reactivity with cynomolgus PDL1. | Immunogen: Recombinant human PDL1 | Host: Alpaca pacous | Isotype: VHH domain of alpaca IgG2b/2c fused to Human IgG1 Fc(mutation) | Conjugate: Unconjugated | Specificity: Human PDL1 | Cross-Reactivity: Cross-reactivity with cynomolgus PDL1 | Purity: Recombinant Expression and Affinity purified | Concentration: 1mg/ml | Formation: Liquid, 10mM PBS (pH 7.{{2469278-96-2} site|{2469278-96-2} Purity & Documentation|{2469278-96-2} In stock|{2469278-96-2} manufacturer} 5), 0.05% sucrose, 0.1% trehalose, 0.01% proclin300, 50% Glycerol | Storage: Store at –20 °C, (Avoid freeze / thaw cycles), Stable for 12 months at -20°C | Background:Programmed death receptor ligand 1 (PD-L1), also known as CD274 or B7H1, is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.Using antibody with Fc(mutation), the background from Fc receptors will be eliminated.
Description2 :
Anti-PDL1, Human antibody is designed for detecting human PDL1 specifically.{{9041-92-3} web|{9041-92-3} Purity & Documentation|{9041-92-3} In stock|{9041-92-3} supplier} Anti-PDL1, Human antibody is recombinant VHH domain of alpaca IgG2b/2c fused to Human IgG1 Fc.PMID:30137860 Based on ELISA, Anti-PDL1, Human antibody reacts with human PDL1, and has reactivity with cynomolgus PDL1.
Immunogen:
Recombinant human PDL1
Host :
Alpaca pacous
Isotype:
VHH domain of alpaca IgG2b/2c fused to Human IgG1 Fc(mutation)
Purity :
Recombinant Expression and Affinity purified
Buffer :
Storage :
Store at –20 °C, (Avoid freeze / thaw cycles), Stable for 12 months at -20°C
Function:
ELISA: 1:4,000-1:10000Flow Cytometry：1:200-1:1000Dilution factors are presented in the form of a range because the optimal dilution is a function of many factors, such as antigen density, permeability, etc. The actual dilution used must be determined empirically.
