Product Name :
OXFBD04
Description:
OXFBD04 is a potent and selective BRD4 inhibitor with an IC50 of 166 nM. OXFBD04 is a potent BET bromodomain ligand with additional modest affinity for the CREBBP bromodomain. OXFBD04 has anti-cancer activity.
CAS:
2231747-03-6
Molecular Weight:
296.32
Formula:
C17H16N2O3
Chemical Name:
3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[hydroxy(pyridin-3-yl)methyl]phenol
Smiles :
CC1ON=C(C)C=1C1=CC(O)=CC(=C1)C(O)C1=CN=CC=C1
InChiKey:
RFDVEAHRRMEOHK-UHFFFAOYSA-N
InChi :
InChI=1S/C17H16N2O3/c1-10-16(11(2)22-19-10)13-6-14(8-15(20)7-13)17(21)12-4-3-5-18-9-12/h3-9,17,20-21H,1-2H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Vudalimab} medchemexpress|{Vudalimab} Immunology/Inflammation|{Vudalimab} Purity & Documentation|{Vudalimab} Description|{Vudalimab} manufacturer|{Vudalimab} Autophagy}
Shelf Life:
≥12 months if stored properly.{{D(+)-Galactosamine} web|{D(+)-Galactosamine} Technical Information|{D(+)-Galactosamine} References|{D(+)-Galactosamine} custom synthesis|{D(+)-Galactosamine} Cancer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:31899978
Additional information:
OXFBD04 is a potent and selective BRD4 inhibitor with an IC50 of 166 nM. OXFBD04 is a potent BET bromodomain ligand with additional modest affinity for the CREBBP bromodomain. OXFBD04 has anti-cancer activity.|Product information|CAS Number: 2231747-03-6|Molecular Weight: 296.32|Formula: C17H16N2O3|Chemical Name: 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[hydroxy(pyridin-3-yl)methyl]phenol|Smiles: CC1ON=C(C)C=1C1=CC(O)=CC(=C1)C(O)C1=CN=CC=C1|InChiKey: RFDVEAHRRMEOHK-UHFFFAOYSA-N|InChi: InChI=1S/C17H16N2O3/c1-10-16(11(2)22-19-10)13-6-14(8-15(20)7-13)17(21)12-4-3-5-18-9-12/h3-9,17,20-21H,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 250 mg/mL (843.68 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|OXFBD04 (0.01-100 μM; 48 hours) inhibits cancer cell lines growth. OXFBD04 (10 µM; for 10, 24, or 48 hours) induces MYC suppression in MCF7 breast cancer cells.|In Vivo:|OXFBD04 has optimised physicochemical properties (LE=0.43; LLE=5.74; SFI=5.96), and good metabolic stability (t1/2=388 min). OXFBD04 has CLint of 3.57 µL/min/mg.|Products are for research use only. Not for human use.|
