Product Name :
Verapamil
Description:
Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research.
CAS:
52-53-9
Molecular Weight:
454.60
Formula:
C27H38N2O4
Chemical Name:
5-((3, 4-dimethoxyphenethyl)(methyl)amino)-2-(3, 4-dimethoxyphenyl)-2-isopropylpentanenitrile
Smiles :
CN(CCCC(C#N)(C(C)C)C1C=C(OC)C(=CC=1)OC)CCC1C=C(OC)C(=CC=1)OC
InChiKey:
SGTNSNPWRIOYBX-UHFFFAOYSA-N
InChi :
InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research.|Product information|CAS Number: 52-53-9|Molecular Weight: 454.60|Formula: C27H38N2O4|Chemical Name: 5-((3, 4-dimethoxyphenethyl)(methyl)amino)-2-(3, 4-dimethoxyphenyl)-2-isopropylpentanenitrile|Smiles: CN(CCCC(C#N)(C(C)C)C1C=C(OC)C(=CC=1)OC)CCC1C=C(OC)C(=CC=1)OC|InChiKey: SGTNSNPWRIOYBX-UHFFFAOYSA-N|InChi: InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (219.{{Nociceptin} site|{Nociceptin} GPCR/G Protein|{Nociceptin} Protocol|{Nociceptin} In Vivo|{Nociceptin} supplier|{Nociceptin} Cancer} 97 mM; Need ultrasonic).{{Fluvoxamine} web|{Fluvoxamine} Neuronal Signaling|{Fluvoxamine} Technical Information|{Fluvoxamine} In Vivo|{Fluvoxamine} custom synthesis|{Fluvoxamine} Autophagy} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:33679749 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|The EverFluor FL Verapamil (EFV) uptake by TR-iBRB2 cells is inhibited by cationic drugs, and inhibits by verapamil in a concentration-dependent manner with an IC50 of 98.0 μM.|In Vivo:|Given orally Verapamil is useful for the prophylaxis of atrioventricular reentry tachycardia, and also in modulating the atrioventricular nodal response in atrial fibrillation. Verapamil is injected i.v. into a femoral vein prior to ischemia. Verapamil (1 mg/kg) significantly decreases the incidence of ventricular arrhythmias including premature ventricular contractions (PVC), ventricular tachycardia (VT) and ventricular fibrillation (VF) for 45-min coronary artery occlusion. Total arrhythmia scores are significantly increased when the heart is subjected to ischemia. Verapamil (1 mg/kg) significantly prevents the enhancement of total arrhythmia scores induced by ischemia.|Products are for research use only. Not for human use.|
