Product Name :
APTO-253
Description:
APTO-253 (LOR-253, LT-253) inhibits c-Myc expression and selectively induces CDKN1A (p21), promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. APTO-253 is also an inducer of KLF4 (Krüppel-like factor 4).
CAS:
916151-99-0
Molecular Weight:
367.38
Formula:
C22H14FN5
Chemical Name:
2-(5-fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline
Smiles :
CC1NC2=CC=C(F)C=C2C=1C1NC2=C(N=1)C1=CC=CN=C1C1=NC=CC=C21
InChiKey:
NIRXBXIPHUTNNI-UHFFFAOYSA-N
InChi :
InChI=1S/C22H14FN5/c1-11-17(15-10-12(23)6-7-16(15)26-11)22-27-20-13-4-2-8-24-18(13)19-14(21(20)28-22)5-3-9-25-19/h2-10,26H,1H3,(H,27,28)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Collagenase, Type I} medchemexpress|{Collagenase, Type I} MMP|{Collagenase, Type I} Biological Activity|{Collagenase, Type I} Purity|{Collagenase, Type I} custom synthesis|{Collagenase, Type I} Cancer}
Shelf Life:
≥12 months if stored properly.{{Hoechst 33342} MedChemExpress|{Hoechst 33342} Autophagy|{Hoechst 33342} Purity & Documentation|{Hoechst 33342} References|{Hoechst 33342} supplier|{Hoechst 33342} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23509865
Additional information:
APTO-253 (LOR-253, LT-253) inhibits c-Myc expression and selectively induces CDKN1A (p21), promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. APTO-253 is also an inducer of KLF4 (Krüppel-like factor 4).|Product information|CAS Number: 916151-99-0|Molecular Weight: 367.38|Formula: C22H14FN5|Chemical Name: 2-(5-fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline|Smiles: CC1NC2=CC=C(F)C=C2C=1C1NC2=C(N=1)C1=CC=CN=C1C1=NC=CC=C21|InChiKey: NIRXBXIPHUTNNI-UHFFFAOYSA-N|InChi: InChI=1S/C22H14FN5/c1-11-17(15-10-12(23)6-7-16(15)26-11)22-27-20-13-4-2-8-24-18(13)19-14(21(20)28-22)5-3-9-25-19/h2-10,26H,1H3,(H,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 73 mg/mL(198.7 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Baojin Wang, et al. Biochem Biophys Res Commun. 2017 Mar 11;484(3):486-492.Andrea Local, et al. Mol Cancer Ther. 2018 Jun;17(6):1177-1186.Products are for research use only. Not for human use.|
