Product Name :
SA4503 2HCl, a sigma-1 receptor agonist.
Description:
SA4503 dihydrochloride is a selective sigma 1 receptor (σ1R) agonist; high affinity for the sigma 1 receptor subtype labeled by(+)-[3H]pentazocine (IC50 = 17.4 +/- 1.9 nM), demonstrating 100-fold less affinity for the sigma 2 receptor.
CAS:
165377-44-6
Molecular Weight:
441.43
Formula:
C23H34Cl2N2O2
Chemical Name:
1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride
Smiles :
Cl.Cl.COC1=CC(CCN2CCN(CCCC3C=CC=CC=3)CC2)=CC=C1OC
InChiKey:
XWOXAKBQEMQMFH-UHFFFAOYSA-N
InChi :
InChI=1S/C23H32N2O2.2ClH/c1-26-22-11-10-21(19-23(22)27-2)12-14-25-17-15-24(16-18-25)13-6-9-20-7-4-3-5-8-20;;/h3-5,7-8,10-11,19H,6,9,12-18H2,1-2H3;2*1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
SA4503 dihydrochloride is a selective sigma 1 receptor (σ1R) agonist; high affinity for the sigma 1 receptor subtype labeled by(+)-[3H]pentazocine (IC50 = 17.4 +/- 1.9 nM), demonstrating 100-fold less affinity for the sigma 2 receptor.|Product information|CAS Number: 165377-44-6|Molecular Weight: 441.43|Formula: C23H34Cl2N2O2|Synonym:|SA-4503|AGY94806|Cutamesine HCl|Cutamesine hydrochloride|SA 4503|Chemical Name: 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride|Smiles: Cl.{{Larotrectinib} medchemexpress|{Larotrectinib} Apoptosis|{Larotrectinib} Biological Activity|{Larotrectinib} References|{Larotrectinib} custom synthesis|{Larotrectinib} Cancer} Cl.COC1=CC(CCN2CCN(CCCC3C=CC=CC=3)CC2)=CC=C1OC|InChiKey: XWOXAKBQEMQMFH-UHFFFAOYSA-N|InChi: InChI=1S/C23H32N2O2.2ClH/c1-26-22-11-10-21(19-23(22)27-2)12-14-25-17-15-24(16-18-25)13-6-9-20-7-4-3-5-8-20;;/h3-5,7-8,10-11,19H,6,9,12-18H2,1-2H3;2*1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 30 mg/mL (67.96 mM; Need ultrasonic and warming)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{KH7} site|{KH7} GPCR/G Protein|{KH7} NF-κB|{KH7} Biological Activity|{KH7} Purity|{KH7} manufacturer} |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|The sigma receptor might be involved in several diseases in the central nervous system.PMID:24576999 Cutamesine, a potent σ1receptor agonist, has 103-fold higher affinity for σ1 (IC50=17.4 nM) than σ2 (IC50=1, 784 nM) sites in guinea pig brain membranes. Cutamesine is 14-fold selective for σ1 (Ki=4.6 nM) over σ2 (Ki=63.1 nM) sites in guinea pig brain homogenates[1]. Cutamesine protects motor neuron NSC34 cells against superoxide dismutase 1 and serum free neurotoxicity. It upregulates the phosphorylation levels of Akt and extracellular signal-regulated kinase (ERK) 1/2[2]. Cutamesine reduces the activation of the MAPK/ERK pathway and down-regulated the ionotropic glutamate receptor, GluR1[3].|In Vivo:|Cutamesine extends the survival time in the SOD1G93A mice[2].|References:|Lever JR, et al. Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse. 2006 May;59(6):350-8.Tuerxun T, et al. SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression. Neurosci Lett. 2010 Jan 29;469(3):303-8.Products are for research use only. Not for human use.|
