Product Name :
Thiazovivin — Rock Inhibitor
Description:
Thiazovivin is a highly potent, selective, and cell-permeable small molecule Rock inhibitor with effective cellular activity ~ 2 μM. It can enhance survival of human embryonic stem cells (hESCs) or iPSCs after single cell dissociation by trypsin, and dramatically improve the reprogramming efficiency of iPSC (>200 folds) from human fibroblasts when used in combination with SB431542 and PD0325091. It has been shown to exhibit better activity than Y27632 in many stem cell assays.
CAS:
1226056-71-8
Molecular Weight:
311.36
Formula:
C15H13N5OS
Chemical Name:
N-Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide
Smiles :
O=C(NCC1C=CC=CC=1)C1=CSC(NC2=CC=NC=N2)=N1
InChiKey:
DOBKQCZBPPCLEG-UHFFFAOYSA-N
InChi :
InChI=1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13-6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Naptumomab} site|{Naptumomab} Biological Activity|{Naptumomab} Data Sheet|{Naptumomab} supplier|{Naptumomab} Epigenetic Reader Domain}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Thiazovivin is a highly potent, selective, and cell-permeable small molecule Rock inhibitor with effective cellular activity ~ 2 μM. It can enhance survival of human embryonic stem cells (hESCs) or iPSCs after single cell dissociation by trypsin, and dramatically improve the reprogramming efficiency of iPSC (>200 folds) from human fibroblasts when used in combination with SB431542 and PD0325091. It has been shown to exhibit better activity than Y27632 in many stem cell assays.|Product information|CAS Number: 1226056-71-8|Molecular Weight: 311.36|Formula: C15H13N5OS|Chemical Name: N-Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide|Smiles: O=C(NCC1C=CC=CC=1)C1=CSC(NC2=CC=NC=N2)=N1|InChiKey: DOBKQCZBPPCLEG-UHFFFAOYSA-N|InChi: InChI=1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13-6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20)|Technical Data|Appearance: Solid Power.{{Sapienic acid} web|{Sapienic acid} Bacterial|{Sapienic acid} NF-κB|{Sapienic acid} Biological Activity|{Sapienic acid} Description|{Sapienic acid} custom synthesis} |Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO up to 100 mM|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24275718 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|Thiazovivin is usually used at 0.5-2 μM final concentration in cell culture.|References:|Lin T, et al. A chemical platform for improved induction of human iPSCs. (2009) Nat. Methods. 6(11), 805-8.Xu Y, et al. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. (2010) Proc. Natl. Acad. Sci. 107, 8129.Products are for research use only. Not for human use.|Documents||
