Product Name :
Z-Ala-Ala-Asn-AMC
Description:
Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC.
CAS:
149697-16-5
Molecular Weight:
565.57
Formula:
C28H31N5O8
Chemical Name:
benzyl N-[(1S)-1-{[(1S)-1-{[(1S)-2-carbamoyl-1-[(4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl]ethyl]carbamoyl}ethyl]carbamoyl}ethyl]carbamate
Smiles :
CC1=CC(=O)OC2=CC(=CC=C12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)OCC1C=CC=CC=1
InChiKey:
WVJTXYIHBUISHX-FIKGOQFSSA-N
InChi :
InChI=1S/C28H31N5O8/c1-15-11-24(35)41-22-12-19(9-10-20(15)22)32-27(38)21(13-23(29)34)33-26(37)16(2)30-25(36)17(3)31-28(39)40-14-18-7-5-4-6-8-18/h4-12,16-17,21H,13-14H2,1-3H3,(H2,29,34)(H,30,36)(H,31,39)(H,32,38)(H,33,37)/t16-,17-,21-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Z-Ala-Ala-Asn-AMC (Cbz-Ala-Ala-Asn-AMC) is the legumain substrate. Overexpressed legumain in 293 HEK-Leg cells potently cleaved CBZ-Ala-Ala-Asn-AMC.|Product information|CAS Number: 149697-16-5|Molecular Weight: 565.57|Formula: C28H31N5O8|Chemical Name: benzyl N-[(1S)-1-{[(1S)-1-{[(1S)-2-carbamoyl-1-[(4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl]ethyl]carbamoyl}ethyl]carbamoyl}ethyl]carbamate|Smiles: CC1=CC(=O)OC2=CC(=CC=C12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)OCC1C=CC=CC=1|InChiKey: WVJTXYIHBUISHX-FIKGOQFSSA-N|InChi: InChI=1S/C28H31N5O8/c1-15-11-24(35)41-22-12-19(9-10-20(15)22)32-27(38)21(13-23(29)34)33-26(37)16(2)30-25(36)17(3)31-28(39)40-14-18-7-5-4-6-8-18/h4-12,16-17,21H,13-14H2,1-3H3,(H2,29,34)(H,30,36)(H,31,39)(H,32,38)(H,33,37)/t16-,17-,21-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (88.{{Sintilimab} web|{Sintilimab} Immunology/Inflammation|{Sintilimab} Biological Activity|{Sintilimab} In stock|{Sintilimab} custom synthesis|{Sintilimab} Autophagy} 41 mM; Need ultrasonic).{{TSLP Protein, Human} medchemexpress|{TSLP Protein, Human} Biological Activity|{TSLP Protein, Human} In stock|{TSLP Protein, Human} supplier|{TSLP Protein, Human} Epigenetics} H2O : Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24456950 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|The first legumain fluorogenic substrate Cbz-Ala-Ala-Asn-AMC based on the P3-P2-P1 sequence Ala-Ala-Asn. The synthetic substrate Cbz-Ala-Ala-Asn-AMC is effectively cleaved by S. mansoni legumain and human legumain with Kms of 90 and 80 uM respectively.|Products are for research use only. Not for human use.|
