Product Name :
EACC
Description:
EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion.
CAS:
864941-31-1
Molecular Weight:
369.37
Formula:
C13H11N3O6S2
Chemical Name:
ethyl N-[2-(5-nitrothiophene-2-amido)thiophene-3-carbonyl]carbamate
Smiles :
CCOC(=O)NC(=O)C1C=CSC=1NC(=O)C1=CC=C(S1)[N+]([O-])=O
InChiKey:
ISLJZDYAPAUORR-UHFFFAOYSA-N
InChi :
InChI=1S/C13H11N3O6S2/c1-2-22-13(19)15-10(17)7-5-6-23-12(7)14-11(18)8-3-4-9(24-8)16(20)21/h3-6H,2H2,1H3,(H,14,18)(H,15,17,19)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Polyinosinic-polycytidylic acid} MedChemExpress|{Polyinosinic-polycytidylic acid} Bcl-2 Family|{Polyinosinic-polycytidylic acid} Immunology/Inflammation|{Polyinosinic-polycytidylic acid} Technical Information|{Polyinosinic-polycytidylic acid} Data Sheet|{Polyinosinic-polycytidylic acid} supplier}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion.|Product information|CAS Number: 864941-31-1|Molecular Weight: 369.37|Formula: C13H11N3O6S2|Chemical Name: ethyl N-[2-(5-nitrothiophene-2-amido)thiophene-3-carbonyl]carbamate|Smiles: CCOC(=O)NC(=O)C1C=CSC=1NC(=O)C1=CC=C(S1)[N+]([O-])=O|InChiKey: ISLJZDYAPAUORR-UHFFFAOYSA-N|InChi: InChI=1S/C13H11N3O6S2/c1-2-22-13(19)15-10(17)7-5-6-23-12(7)14-11(18)8-3-4-9(24-8)16(20)21/h3-6H,2H2,1H3,(H,14,18)(H,15,17,19)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 16.88 mg/mL (45.70 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Vitamin B12} web|{Vitamin B12} Endogenous Metabolite|{Vitamin B12} Protocol|{Vitamin B12} Formula|{Vitamin B12} manufacturer|{Vitamin B12} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:35901518 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|EACC blocks autophagosome-lysosome fusion but does not affect endo-lysosomal function. EACC inhibits autophagy by preventing SNARE Stx17 loading on autophagosomes. EACC does not affect RABs, tethers, and lysosomal SNARE but prevents their interaction with LC3 and Stx17.|Products are for research use only. Not for human use.|
