Tocilizumab Biosimilar, Human IL-6R Monoclonal Antibody

Additional Information:
| Tocilizumab Biosimilar, IL-6R Monoclonal Antibody Recombinant Humanized IgG1 Monoclonal Antibody. |Isotype: Human IgG1 kap|The anti-human IL-6R monoclonal antibody tocilizumab biosimilar was produced in mammal cells. |Specificity/Sensitivity: The in vivo grade tocilizumab biosimilar specifically binds to the human interleukin-6 receptor (IL-6R). |Applications: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological |0.2 uM filtered solution, pH 6.5, no stabilizers or preservatives. |Endotoxin: |Purity: >95% by SDS-|The research grade tocilizumab biosimilar is shipped with ice |Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |Background What is tocilizumab biosimilar research grade? Tocilizumab biosimilar uses the same protein sequences as the therapeutic antibody tocilizumab. Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. Interleukin 6 (IL-6) is a pro-inflammatory cytokine produced by cells including T-cells, B-cells, lymphocytes, monocytes, fibroblasts. IL-6 rapidly induces C-reactive protein, serum amyloid A, fibrinogen, haptoglobin, and α-1-antichymotrypsin while inhibiting production of fibronectin, albumin, and transferrin. IL-6 also induces antibody production, induces cytotoxic T-cell different and inhibits regulatory T-cell different Tocilizumab binds soluble and membrane bound IL-6 receptors, preventing IL-6 med inflammation. Syd Labs also provides the following anti-IL antibody biosimilar proteins: Pascolizumab Biosimilar, research grade, anti-human IL-4 monoclonal antibody Sarilumab Biosimilar, research grade, anti-human IL-6/IL-6R monoclonal antibody Secukinumab Biosimilar, research grade, anti-human IL-17/IL-17a monoclonal antibody Br Biosimilar, research grade, anti-human IL-12/IL-23 monoclonal antibody Ustekinumab Biosimilar, research grade, anti-human IL-12/IL-23 monoclonal antibody