TNF alpha Antibody

Background:
Tumor necrosis factor-alpha (TNFA) also kowns as TNFR1, It is a potent cytokine, elicits a broad spectrum of biologic responses which are mediated by binding to a cell surface receptor. There are 2 different proteins that serve as major receptors for TNF-alpha, one associated with myeloid cells and one associated with epithelial cells. TNFR1 maps to 12p13. TNFR1 signaling is also known to activate the transcription factor NF-kappa B and promote survival.Tumor necrosis factor, alpha-induced protein 1 (endothelial), also known as TNFAIP1, is a human gene.The gene, present in single copy, was located in the 17q22-q23 region. This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. The protein is involved in the primary response of the endothelium to TNF. PA000215-PA1079: TNFα Polyclonal Antibody Rabbit Polyclonal Antibody. Specificity/Sensitivity: Human, mouse, rat. No cross reactivity with other proteins. Applications: Western blot: At 1-2 ug/ml with the appropriate system to detect TNFa in cells and tissues. Immunohistochemistry(P): At 0.5-1 ug/ml to detect TNFa in formalin fixed and paraffin embedded tissues. Reactivity: Human, Mouse, Rat. Immunogen: A peptide mapping at the C-terminal of TNFα of human origin, different from the mouse sequence by one amino acid, and rat sequence by three amino acids. Purification: Immunogen affinity purified. Form of Antibody: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3. Isotype: Rabbit IgG. Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. Other TNFα Antibody: TNFα Monoclonal Antibody TNF alpha Proteins: Recombinant Rabbit TNFα Protein Recombinant Mouse TNFα Protein Recombinant Human TNFα Protein, His Tag Recombinant Canine TNFα Protein Recombinant Human TNFα Protein TNFα ELISA Kits: Rat TNFα ELISA Kit Mouse TNFα ELISA Kit Human TNFα ELISA Kit