Product Name :
Diazoxide
Description:
Diazoxide (Sch-6783) is an ATP-sensitive potassium channel activator, has the potential for hyperinsulinism treatment.
CAS:
364-98-7
Molecular Weight:
230.67
Formula:
C8H7ClN2O2S
Chemical Name:
7-chloro-3-methyl-4H-1λ⁶,2,4-benzothiadiazine-1,1-dione
Smiles :
CC1NC2=CC=C(Cl)C=C2S(=O)(=O)N=1
InChiKey:
GDLBFKVLRPITMI-UHFFFAOYSA-N
InChi :
InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{4-Methylumbelliferyl} site|{4-Methylumbelliferyl} Metabolic Enzyme/Protease|{4-Methylumbelliferyl} Protocol|{4-Methylumbelliferyl} Formula|{4-Methylumbelliferyl} supplier|{4-Methylumbelliferyl} Cancer}
Additional information:
Diazoxide (Sch-6783) is an ATP-sensitive potassium channel activator, has the potential for hyperinsulinism treatment.{{Racotumomab} medchemexpress|{Racotumomab} Protocol|{Racotumomab} In Vivo|{Racotumomab} manufacturer|{Racotumomab} Epigenetic Reader Domain} |Product information|CAS Number: 364-98-7|Molecular Weight: 230.67|Formula: C8H7ClN2O2S|Chemical Name: 7-chloro-3-methyl-4H-1λ⁶,2,4-benzothiadiazine-1,1-dione|Smiles: CC1NC2=CC=C(Cl)C=C2S(=O)(=O)N=1|InChiKey: GDLBFKVLRPITMI-UHFFFAOYSA-N|InChi: InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 35 mg/mL (151.PMID:34816786 73 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Diazoxide (Sch-6783) has a number of physiological effects, including lowering the blood pressure and rectifying hypoglycemia. Diazoxide has powerful protective properties against cardiac ischemia. Diazoxide (Sch-6783) could protect NSC-34 neurons against the main sources of neurodegenerative damage. Diazoxide increases Nrf2 nuclear translocation in NSC-34 motoneurons and prevents endogenous oxidative damage.|In Vivo:|Diazoxide (Sch-6783) attenuates postresuscitation brain injury, protects mitochondrial function, inhibits brain cell apoptosis, and activates the PKC pathway by opening mitoKATP channels. Treatment with Diazoxide (Sch-6783) in wild-type mice decreases intraocular pressure (IOP) by 21.5±3.2% with an absolute IOP reduction of 3.9 ± 0.6 mm Hg.|Products are for research use only. Not for human use.|
