Product Name :
DO34
Description:
DO34 is a highly potent, selective and centrally active diacylglycerol lipase (DAGL) inhibitor, with an IC50 of 6 nM for DAGLα conversion of SAG to 2-AG, and an IC50 for DAGLβ.
CAS:
1848233-58-8
Molecular Weight:
531.53
Formula:
C26H28F3N5O4
Chemical Name:
tert-butyl 3-benzyl-4-{4-[4-(trifluoromethoxy)phenyl]-1H-1,2,3-triazole-1-carbonyl}piperazine-1-carboxylate
Smiles :
CC(C)(C)OC(=O)N1CC(CC2C=CC=CC=2)N(CC1)C(=O)N1C=C(N=N1)C1=CC=C(C=C1)OC(F)(F)F
InChiKey:
CQGMWUWJVBKTRM-UHFFFAOYSA-N
InChi :
InChI=1S/C26H28F3N5O4/c1-25(2,3)38-24(36)32-13-14-33(20(16-32)15-18-7-5-4-6-8-18)23(35)34-17-22(30-31-34)19-9-11-21(12-10-19)37-26(27,28)29/h4-12,17,20H,13-16H2,1-3H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
DO34 is a highly potent, selective and centrally active diacylglycerol lipase (DAGL) inhibitor, with an IC50 of 6 nM for DAGLα conversion of SAG to 2-AG, and an IC50 for DAGLβ.|Product information|CAS Number: 1848233-58-8|Molecular Weight: 531.53|Formula: C26H28F3N5O4|Chemical Name: tert-butyl 3-benzyl-4-{4-[4-(trifluoromethoxy)phenyl]-1H-1,2,3-triazole-1-carbonyl}piperazine-1-carboxylate|Smiles: CC(C)(C)OC(=O)N1CC(CC2C=CC=CC=2)N(CC1)C(=O)N1C=C(N=N1)C1=CC=C(C=C1)OC(F)(F)F|InChiKey: CQGMWUWJVBKTRM-UHFFFAOYSA-N|InChi: InChI=1S/C26H28F3N5O4/c1-25(2,3)38-24(36)32-13-14-33(20(16-32)15-18-7-5-4-6-8-18)23(35)34-17-22(30-31-34)19-9-11-21(12-10-19)37-26(27,28)29/h4-12,17,20H,13-16H2,1-3H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 100 mg/mL (188.14 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.{{Besifovir} web|{Besifovir} HBV|{Besifovir} Technical Information|{Besifovir} In stock|{Besifovir} manufacturer|{Besifovir} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{AZD4635} site|{AZD4635} GPCR/G Protein|{AZD4635} Purity & Documentation|{AZD4635} In stock|{AZD4635} supplier|{AZD4635} Epigenetic Reader Domain} |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|DO34 is a highly potent, selective and centrally active DAGL inhibitor, with an IC50 of 6 nM for DAGLα conversion of SAG to 2-AG, as determined using a real-time, fluorescence-based natural substrate assay with membrane lysates from HEK293T cells expressing recombinant human DAGLα.PMID:23381626 It is also confirmed that and DO34 is a potent inhibitor of DAGLβ with IC50 of 3-8 nM.|In Vivo:|DO34 (compound 39) prevents fasting-induced refeeding of mice, which is typical cannabinoid CB1-receptor mediated behavior. DO34 (comound 39) reduces brain 2-AG levels in dose- and time dependent manner. DO34 could block the tonic CB1 activation. AM251 significantly increases basal PF-EPSCs in MAGL-TKO mice, and the effect of AM251 is blocked by the DAGL inhibitor DO34.|Products are for research use only. Not for human use.|
