TERT Antibody

Additional Information:
|Introduction TERT(Telomerase reverse transcriptase), is a catalytic subunit of the enzyme telomerase. Its absence (usually as a result of a chromosomal mutation) is assoc with the disorder Cri du chat. The TERT gene was mapped to chromosome 5p15.33T by Meyerson, M. Elomerase lengthens telomeres in DNA strands, thereby allowing senescent cells that would otherwise become postmitotic and undergo apoptosis to exceed the Hayflick limit and become potent immortal, as is often the case with cancerous cells. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells, resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mice suggest that telomerase also |WB 0.1-0.5 ug/ml. Reactivity: Rat, Mouse. Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of mouse TERT, identical to the related rat sequence. Purification: Immunogen affinity purified. Form of Antibody: Lyophilized. Isotype: Rabbit IgG. Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original v after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.