Cbfa2t2 Antibody

Additional Information:
|Introduction Protein CBFA2T2 is a protein that in humans is encoded by the CBFA2T2 gene. In acute myeloid leukem espec in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5′-region of the RUNX1 (AML1) gene fused to the 3′-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to assoc with the nuclear corepressor/histone deacetylase complex to block hematopoietic different The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript var are thought to exist for this gene, but the full-length natures of only three have been described. | Cbfa2t2 (MTGR1) Monoclonal Antibody Rat Monoclonal Antibody. Specificity/Sensitivity: Anti-mouse Cbfa2t2 (MTGR1). Applications: Western blotting: starting from 1:1000, dilution range 1:250-1:2500. Reactivity: Mouse. Immunogen: MTGR1 peptide couple with BSA. Purification: purified from culture supernatant using a protein G column. Form of Antibody: 0.5 ug/ml in PBS containing 0.1% sodium azide as a preservative. Clone No: KT42. Isotype: Rat IgG2c. Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original v after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.