Product Name :
DC_C66
Description:
DC_C66 is a cell-permeable, selective coactivator associated arginine methyltransferase 1 (CARM1) inhibitor with an IC50 of 1.8 μM. DC_C66 has a good selectivity for CARM1 against PRMT1 (IC50=21 μM), PRMT6 (IC50= 47μM), and PRMT5.
CAS:
108181-00-6
Molecular Weight:
404.48
Formula:
C28H22NO2
Chemical Name:
26-(ethoxycarbonyl)-25λ⁵-azahexacyclo[12.12.0.0²,⁷.0⁸,¹³.0¹⁶,²⁵.0¹⁷,²²]hexacosa-1(26),2,4,6,8,10,12,14,16(25),17,19,21-dodecaen-25-ylium
Smiles :
CCOC(=O)C1=C2C3=CC=CC=C3C3=CC=CC=C3C2=CC2C3=CC=CC=C3CC[N+]=21
InChiKey:
DIVJVPWHSSAIPN-UHFFFAOYSA-N
InChi :
InChI=1S/C28H22NO2/c1-2-31-28(30)27-26-23-14-8-7-12-21(23)20-11-5-6-13-22(20)24(26)17-25-19-10-4-3-9-18(19)15-16-29(25)27/h3-14,17H,2,15-16H2,1H3/q+1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Clomipramine} medchemexpress|{Clomipramine} Neuronal Signaling|{Clomipramine} Technical Information|{Clomipramine} Formula|{Clomipramine} manufacturer|{Clomipramine} Epigenetics}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
DC_C66 is a cell-permeable, selective coactivator associated arginine methyltransferase 1 (CARM1) inhibitor with an IC50 of 1.{{Hydrochlorothiazide} medchemexpress|{Hydrochlorothiazide} TGF-beta/Smad|{Hydrochlorothiazide} Protocol|{Hydrochlorothiazide} References|{Hydrochlorothiazide} supplier|{Hydrochlorothiazide} Epigenetic Reader Domain} 8 μM. DC_C66 has a good selectivity for CARM1 against PRMT1 (IC50=21 μM), PRMT6 (IC50= 47μM), and PRMT5.|Product information|CAS Number: 108181-00-6|Molecular Weight: 404.48|Formula: C28H22NO2|Chemical Name: 26-(ethoxycarbonyl)-25λ⁵-azahexacyclo[12.12.0.0²,⁷.0⁸,¹³.0¹⁶,²⁵.0¹⁷,²²]hexacosa-1(26),2,4,6,8,10,12,14,16(25),17,19,21-dodecaen-25-ylium|Smiles: CCOC(=O)C1=C2C3=CC=CC=C3C3=CC=CC=C3C2=CC2C3=CC=CC=C3CC[N+]=21|InChiKey: DIVJVPWHSSAIPN-UHFFFAOYSA-N|InChi: InChI=1S/C28H22NO2/c1-2-31-28(30)27-26-23-14-8-7-12-21(23)20-11-5-6-13-22(20)24(26)17-25-19-10-4-3-9-18(19)15-16-29(25)27/h3-14,17H,2,15-16H2,1H3/q+1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23399686 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|DC_C66 (6.25-100 μM; 24-72 hours) exhibits antiproliferation activity in several CARM1-associated cancer cell lines.|Products are for research use only. Not for human use.|
