Product Name :
Spartalizumab Biosimilar, PD-1 Monoclonal Antibody
EN
programmed cell death protein 1, PD1, CD279, cluster of differentiation 279
Source:
The anti-human PD-1 monoclonal antibody spartalizumab biosimilar was produced in mammalian cells.
Molecular Weight:
Activity :
Purity:
>95% by SDS-PAGE under reducing conditions and HPLC.
Endotoxin :
< 1 EU per 1 mg of the protein by the LAL method.
Formulation:
Reconstitution :
Shipping:
The research grade spartalizumab biosimilar is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:
/strong>Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Form of Antibody :
0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives.
Clone:
Isotype:
Human IgG4 kappa.
Background:
Spartalizumab Biosimilar uses the same protein sequences as the therapeutic antibody spartalizumab. A humanized monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed death-1 (PD-1, PCD-1), with immune checkpoint inhibitory and antineoplastic activities. Upon administration, spartalizumab binds to PD-1 expressed on activated T cells and blocks the interaction with its ligands, programmed cell death 1 ligand 1 (PD-L1, PD-1L1) and PD-1 ligand 2 (PD-L2, PD-1L2). The inhibition of ligand binding prevents PD-1-mediated signaling and results in both T-cell activation and the induction of T-cell-mediated immune responses against tumor cells. PD-1, an immunoglobulin (Ig) superfamily transmembrane protein and inhibitory receptor, negatively regulates T-cell activation. Syd Labs provides the following research grade anti-PD-L1 / PD-1 antibody biosimilar proteins: Atezolizumab biosimilar, research grade, anti-human PD-L1 monoclonal antibody Avelumab biosimilar, research grade, anti-human PD-L1 monoclonal antibody Camrelizumab biosimilar, research grade, anti-human PD-1 monoclonal antibody Cemiplimab biosimilar, research grade, anti-human PD-1 monoclonal antibody Durvalumab biosimilar, research grade, anti-human PD-L1 monoclonal antibody Nivolumab biosimilar, research grade, anti-human PD-1 monoclonal antibody Pembrolizumab biosimilar, research grade, anti-human PD-1 monoclonal antibody Spartalizumab biosimilar, research grade, anti-human PD-1 monoclonal antibody PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. Syd Labs provides the following research grade anti-CTLA-4 antibody biosimilars: Ipilimumab Biosimilar, research grade, anti-human CTLA-4 monoclonal antibody Tremelimumab Biosimilar, research grade, anti-human CTLA-4 monoclonal antibody Syd Labs provides the following anti-mouse PD-L1 / PD-1 antibodies: In vivo grade recombinant anti-mouse PD1 monoclonal antibodies (Clone 29F.1A12.1) In vivo grade recombinant anti-mouse PD-1 monoclonal antibodies (Clone RMP1-14.1) In vivo grade recombinant anti-mouse PD-L1 monoclonal antibodies (Clone 10F.9G2.1)
Additional Information:
| S|Human IgG4 kap|The anti-human PD-1 monoclonal antibody s|The in vivo grade s|ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological |0.2 uM filtered solution, pH 7.4, no stabilizers or preservatives. |Endotoxin: |Purity: >95% by SDS-|The research grade s|Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |Background S|Atezolizumab biosimilar, research grade, anti-human PD-L1 monoclonal antibody Avelumab biosimilar, research grade, anti-human PD-L1 monoclonal antibody Camrelizumab biosimilar, research grade, anti-human PD-1 monoclonal antibody Cemiplimab biosimilar, research grade, anti-human PD-1 monoclonal antibody Durvalumab biosimilar, research grade, anti-human PD-L1 monoclonal antibody Nivolumab biosimilar, research grade, anti-human PD-1 monoclonal antibody Pembrolizumab biosimilar, research grade, anti-human PD-1 monoclonal antibody S|Ipilimumab Biosimilar, research grade, anti-human CTLA-4 monoclonal antibody Tremelimumab Biosimilar, research grade, anti-human CTLA-4 monoclonal antibody Syd Labs provides the following anti-mouse PD-L1 / PD-1 antibodies: In vivo grade recombinant anti-mouse PD1 monoclonal antibodies (Clone 29F.1A12.1) In vivo grade recombinant anti-mouse PD-1 monoclonal antibodies (Clone RMP1-14.1) In vivo grade recombinant anti-mouse PD-L1 monoclonal antibodies (Clone 10F.9G2.1)
Related websites: https://www.medchemexpress.com/antibodies.html
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