Product Name :
SMAD4 Antibody
EN
DPC4 Antibody
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SMAD4 plays a pivotal role in signal transduction of the transforming growth factor beta superfamily cytokines by mediating transcriptional activation of target genes. Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Mutational inactivation of SMAD4 causes TGF-beta unresponsiveness and gave a basis for understanding the physiologic role of this gene in tumorigenesis. Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases. PA000086-PA1953: Smad4 Polyclonal Antibody Rabbit Polyclonal Antibody. Applications: WB 0.1-0.5 ug/ml. Reactivity: Human, Rat, Mouse. Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of human SMAD4, identical to the related rat and mouse sequences. Purification: Immunogen affinity purified. Form of Antibody: Lyophilized. Reconstitution: 0.2 ml of distilled water will yield a concentration of 500 ug/ml. Isotype: Rabbit IgG. Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
Additional Information:
|Background SMAD4 plays a pivotal role in signal transduction of the transforming growth factor beta superfamily cytokines by med transcriptional activation of target genes. Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Mutational inactivation of SMAD4 causes TGF-beta unresponsiveness and gave a basis for understanding the physiologic role of this gene in tumorigenesis. Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases. | Smad4 Polyclonal Antibody Rabbit Polyclonal Antibody. Applications: WB 0.1-0.5 ug/ml. Reactivity: Human, Rat, Mouse. Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of human SMAD4, identical to the related rat and mouse sequences. Purification: Immunogen affinity purified. Form of Antibody: Lyophilized. Reconstitution: 0.2 ml of distilled water will yield a concentration of 500 ug/ml. Isotype: Rabbit IgG. Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original v after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
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