SMAD2 Antibody

Additional Information:
|Introduction Smad2(Mothers against decapentaplegic homolog 2), also known as MADR2, MADH2, SMAD family member 2 or SMAD2, is a protein that in humans is encoded by the SMAD2 gene. MAD homolog 2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ‘mothers against decapentaplegic’ (Mad) and the C. elegans gene Sma. Eppert et al. (1996) mapped the MADR2 gene close to DPC4 at 18q21, a region which is frequently deleted in colorectal cancers. Riggins et al. (1996) mapped the human MADH2 gene to 18q21. Nakao et al. (1997) refined the localization of the SMAD2 gene to 18q21.1, approximately 3 Mb proximal to DPC4, by fluorescence in situ hybridization. SMAD2 med the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and different This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. | Smad2 Polyclonal Antibody Rabbit Polyclonal Antibody. Applications: WB: 0.1-0.5 ug/ml IHC-P: 0.5-1 ug/ml ICC 0.5-1ug/ml. Reactivity: Human, Rat, Mouse. Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of human Smad2, identical to the related rat and mouse sequences. Purification: Immunogen affinity purified. Form of Antibody: Lyophilized. Isotype: Rabbit IgG. Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original v after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing. |Other SMAD2 Antibodies: Smad2 Polyclonal Antibody Smad2 (Ab-467) Polyclonal Antibody Smad2 (Ab-255) Polyclonal Antibody Smad2 (Ab-250) Polyclonal Antibody Smad2 (Ab-245) Polyclonal Antibody Smad2 (Ab-220) Polyclonal Antibody