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Product Name :
Ranibizumab Biosimilar, VEGF Monoclonal Antibody Fab

EN
Anti-VEGF-A Humanized Monoclonal Antibody (Fab)

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Background:
The humanized anti-VEGF-A monoclonal antibody drug Bevacizumab (trade name Avastin, Genentech/Roche) is the first clinically available angiogenesis inhibitor in the United States. The humanized anti-VEGF-A monoclonal antibody fragment (Fab) Ranibizumab (trade name Lucentis, Genentech) is derived from the same parent mouse antibody as bevacizumab. Both antibody drugs produce angiogenesis inhibition and slow the growth of new blood vessels. Ranibizumab is much smaller than the parent complete antibody but shows stronger binding to VEGF-A after affinity maturation. Ranibizumab can also be used to treat the “wet” type of age-related macular degeneration (AMD, also ARMD), a common form of age-related vision loss. Vascular endothelial growth factor A (VEGF-A) stimulates angiogenesis in a variety of cancers, including colorectal, lung, breast, glioblastoma, kidney, and ovarian cancers. Syd Labs also provides the following VEGF-A antibody biosimilar protein: Bevacizumab Biosimilar (complete antibody produced in CHO) Syd Labs also provides the following research grade antibody biosimilar proteins: Bevacizumab Biosimilar, research grade (VEGF-A) Ranibizumab Biosimilar, research grade (VEGF-A, Fab produced in E. coli) Cetuximab Biosimilar, research grade (HER1, ErbB-1, EGFR) Panitumumab Biosimilar, research grade (HER1, ErbB-1, EGFR) Trastuzumab Biosimilar, research grade (HER2, ErbB-2, c-neu) Pertuzumab Biosimilar, research grade (HER2, ErbB-2, c-neu) Infliximab biosimilar, research grade (TNF alpha) Adalimumab biosimilar, research grade (TNF alpha) Rituximab biosimilar, research grade (CD20) Denosumab biosimilar, research grade (RANKL, RANK ligand, OPGL, TNFSF11, CD254, TRANCE, ODF) Palivizumab Biosimilar, research grade (RSV) Omalizumab biosimilar, research grade (IgE) Eculizumab biosimilar, research grade (C5)

Additional Information:
| Ranibizumab Biosimilar, Human VEGF Monoclonal Antibody Fragment (Fab) Recombinant Humanized Monoclonal Antibody Fragment (Fab) generated from the same |The research grade Fab protein ranibizumab was produced in the ranibizumab biosimilar E.coli cell line. Specificity/Sensitivity: The Fab protein ranibizumab specifically binds to the human VEGF-A. Applications: Functional assay, neutralization. Form of Antibody: 0.2 uM filtered solution, pH 5.3, no stabilizers or preservatives. Endotoxin: Purity: >95% by SDS-|The Fab protein ranibizumab is shipped with ice |Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied. |Background The humanized anti-VEGF-A monoclonal antibody drug Bevacizumab (trade name Avastin, Genentech/Roche) is the first clinically available angiogenesis inhibitor in the United States. The humanized anti-VEGF-A monoclonal antibody fragment (Fab) Ranibizumab (trade name Lucentis, Genentech) is derived from the same |Bevacizumab Biosimilar (complete antibody produced in CHO) Syd Labs also provides the following research grade antibody biosimilar proteins: Bevacizumab Biosimilar, research grade (VEGF-A) Ranibizumab Biosimilar, research grade (VEGF-A, Fab produced in E. coli) Cetuximab Biosimilar, research grade (HER1, ErbB-1, EGFR) Panitumumab Biosimilar, research grade (HER1, ErbB-1, EGFR) Trastuzumab Biosimilar, research grade (HER2, ErbB-2, c-neu) Pertuzumab Biosimilar, research grade (HER2, ErbB-2, c-neu) Infliximab biosimilar, research grade (TNF alpha) Adalimumab biosimilar, research grade (TNF alpha) Rituximab biosimilar, research grade (CD20) Denosumab biosimilar, research grade (RANKL, RANK ligand, OPGL, TNFSF11, CD254, TRANCE, ODF) Palivizumab Biosimilar, research grade (RSV) Omalizumab biosimilar, research grade (IgE) Eculizumab biosimilar, research grade (C5)

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: signsin1dayinc