N induced by Dox as reflected by reduced TBARS and higher GSH values [Figures 4 and 5]. It can be noteworthyCreatinine (mg dL-1) 0.56 0.02 0.86b 0.17 0.62a 0.14 1.11c 0.aUrea (mg dL-1) 26.6a five.31 42.1b three.80 27.3a 4.01 66.2c three.Data expressed as mean SD of n = six rats (P 0.05), bFR250 = FRSACE 250 mg kg-1, FR250 = FRSACE 500 mg kg-1, Dox = doxorubicin, cValues carrying various superscripts a, b, c in columns vary considerably from every other (P 0.05)abcdFigure one: Result of FRSACE on serum albumin, globulin and A/G ratio. Data expressed as imply SD of n = 6 rats (P 0.05). Bars carrying different superscripts a, b, c vary significantly from each other (P 0.05). Values above every bar represents A/G ratioFigure 2: (a) Part from the kidney of handle rats displaying standard glomeruli.AR7 (b) Area in the kidney of untreated rats displaying focal glomerular and tubular harm with mononuclear infiltrate. (c) Part from the kidney of FRSACE-treated rats (250 mg kg-1) showing shrunken glomeruli. (d) Segment with the kidney of FRSACE-treated rats (500 mg kg-1) displaying normal glomeruli *NG = regular glomerulus, SG = shrunken glomerulus, FGD = focal glomerular injury, FTD = focal tubular damage, MNI = mononuclear infiltratePharmacognosy Magazine | April-June 2013 | Vol 9 | IssueAhmed, et al.Ampicillin sodium : Result of Ficus racemosa towards doxorubicin toxicityabcd Figure four: TBARS amounts in kidney and testis. Data expressed as indicate SD of n = six rats (P 0.05)Figure three: (a) Part in the testis of handle rats exhibiting typical seminiferous tubules containing sperms, (b) Section in the testis of untreated rats showing harm to the seminiferous tubules with damaged basement membrane and necrosed lining epithelium, (c) Section on the testis of FRSACE-treated rats (250 mg kg-1) exhibiting a number of sperms, (d) Section with the testis of FRSACE-treated rats (500 mg kg-1) showing more number of normal seminiferous tubules containing sperms *VC: vacuolation of the lining epithelium cells, SS: seminiferous tubules containing sperms, SWS: seminiferous tubules with no sperms, DBM: broken basement membrane, NE: necrosed epithelial cells, MNI: mononuclear infiltratethe unique bioactive compound(s) from F. racemosa bark for its optimum utilization as being a therapeutic agent to derive greatest advantages of doxorubicin as an anticancer drug by cutting down its toxic effects considerably.
THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 288, NO. 31, pp. 227212733, August two, 2013 2013 through the American Society for Biochemistry and Molecular Biology, Inc. Published within the U.PMID:32695810 S.A.KHARON1 Mediates Flagellar Targeting of the Glucose Transporter in Leishmania mexicana and is Vital for Viability of Infectious Intracellular Amastigotes*Received for publication, May well seven, 2013, and in revised kind, June twelve, 2012 Published, JBC Papers in Press, June 13, 2013, DOI 10.1074/jbc.M113.Khoa D. Tran, Dayana Rodriguez-Contreras, Danielle P. Vieira1, Phillip A. Yates, Larry David Wandy Beatty , Johannes Elferich and Scott M. Landfear3 From your Departments of Molecular Microbiology and Immunology, �Biochemistry and Molecular Biology, and roteomics Shared Resource, Oregon Wellbeing Science University, Portland, Oregon 97239 as well as Molecular Microbiology Imaging Facility, Washington University College of Medication, St. Louis, MissouriBackground: The mechanism for selectively focusing on membrane proteins to your flagellum of kinetoplastid parasites is unknown. Final results: We’ve identified a novel protein, KHARON1, and that is significant for the flagel.
