Ression(S11).Inhumans,STATmutations resultinrelativeGHinsensitivityandgrowthretardation(32).GH alsoinducesearlyresponsegenesthatprecedecellgrowthanddifferentiationsignals(33)mediatedbyCCAATenhancer inding proteinandserumresponseelementsitesonthec-fospromoter.TheGHRmayalsotranslocatetothenucleusbytheimportin /pathwayinconjunctionwithcoactivatoractivator(CoAA). Genetargetsfornuclear-mediatedGHRactionarepredominantlyproproliferative.ForcedGHRtargetingtothecellnucleus alsoenhancescellproliferationandtransformationresponsivenesstoautocrine-derivedGH.Therefore,CoAAandactivatedSTAT5 arebothrequiredforGH-dependentproproliferativeactionsof nuclearGHR(34). STAT5b mediates sexually dimorphic...